胆固醇-聚乙二醇-马来酰亚胺

胆固醇-聚乙二醇-马来酰亚胺 - Names and Identifiers

Name	Cholesterol PEG Maleimide, CLS-PEG-Mal
Synonyms	CLS-PEG-Mal CHOL-PEG-Mal Cholesterol-PEG-Maleimide Cholesterol PEG Maleimide, CLS-PEG-Mal

胆固醇-聚乙二醇-马来酰亚胺 - Physico-chemical Properties

Storage Condition

-20℃

胆固醇-聚乙二醇-马来酰亚胺 - Introduction

Cholesterol PEG Maleimide, CLS-PEG-Mal(CLS-PEG-Mal) is a chemical compound that has the following properties and uses:

Nature:
- CLS-PEG-Mal is a polymer compound whose chemical structure contains cholesterol, polyethylene glycol (PEG) and maleimide groups.
-Cholesterol is a lipid substance, which is lipophilic and can increase the solubility and penetration of compounds.
-Polyethylene glycol is a biocompatible polymer that can enhance the solubility of compounds and extend their circulating half-life.
-Maleimide group is a reactive group that can react with thiol (-SH)-containing compounds to Michael addition reaction of thiol and maleimide.

Use:
- CLS-PEG-Mal are commonly used as carrier materials in the field of biomedicine for drug loading and targeted delivery of drugs.
-Because cholesterol can interact with cell membranes, CLS-PEG-Mal can be used to build targeted drug delivery systems for specific tissues or cell types.
- CLS-PEG-Mal can also be coupled with thiol-containing biomolecules (such as antibodies, proteins, etc.) to construct nanoparticles or aggregates for targeted drug delivery.

Preparation Method:
-The preparation of CLS-PEG-Mal generally involves coupling a PEG having a maleimide group to cholesterol.
-A specific method comprises reacting a PEG containing a maleimide group with a cholesterol molecule to form a Cholesterol PEG Maleimide, CLS-PEG-Mal.

Safety Information:
- CLS-PEG-Mal is a biocompatible substance and is generally considered safe.
-However, care should still be taken to comply with laboratory safety practices during use and avoid contact with skin, eyes or inhalation.
-If you accidentally touch or eat, please seek medical help and provide the product safety data sheet to the doctor for reference.

Last Update：2024-04-09 15:18:08