Molecular Formula | C34H63N5O9 |
Molar Mass | 685.89 |
Density | 1.1340 (rough estimate) |
Melting Point | 233°C (dec.)(lit.) |
Boling Point | 695.91°C (rough estimate) |
Specific Rotation(α) | D27 -90.3° (c = 0.288 in methanol) |
Flash Point | 557.1°C |
Water Solubility | It is soluble in 10% (v/v) acetic acid in methanol (9:1 methanol:acetic acid) (1 mg/ml), ethanol (1-2 mg/ml with heat up to 60°C), DMSO (5 mg/ml), methanol (1 mg/ml), and acetic acid. Insoluble in ben |
Solubility | 10% acetic acid in methanol: 1mg/mL |
Vapor Presure | 0mmHg at 25°C |
Appearance | Solid |
Color | Colorless needles |
BRN | 2201362 |
pKa | 4.17±0.10(Predicted) |
Storage Condition | 2-8°C |
Stability | Stable. Incompatible with strong bases, strong acids. |
Sensitive | Sensitive to heat |
Refractive Index | 1.7500 (estimate) |
MDL | MFCD00060740 |
Use | It has inhibitory effects on various kininogenases, trypsin, chymotrypsin, plasmin, pepsin, etc., and can inhibit aspartic protease. |
In vitro study | Pepstatin A exhibits potent inhibitory effects on aspartic proteases such as proteins Cathepsin D and E. In HIV-infected H9 cells, pepstatin A inhibits the synthesis of some intracellular HIV gag proteins without significant toxicity to HIV-infected cells. Pepstatin A inhibits osteoclast proliferation by blocking ERK signaling and inhibiting the expression of nfatc1. |
In vivo study | Pepstatin (Pepstatin A) has a very low toxicity, with LD 50 s of 1090 mg/kg, 875 mg/kg, 820 mg/kg and 450 mg/kg for mice, rats, rabbits, and dogs by i.p. route, and > 2000 mg/kg for all species by oral route. Pepstatin (0.5-50 mg/kg, p.o.) suppresses stomach ulceration of the pylorus in ligated Shay rats. |
Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
WGK Germany | 2 |
RTECS | SC6155000 |
FLUKA BRAND F CODES | 10 |
HS Code | 29241990 |
Toxicity | LD50 in mice, rats, rabbits, dogs (mg/kg): 1090, 875, 820, 450 i.p.; all >2000 orally (Umezawa, 1970) |
Reference Show more | 1. Wang Lijuan, Lu Junzhang, Li Mingwei, etc. Effect of compound Zhuye gypsum granule on immune function in rabbits with acute radiation esophageal injury [J]. Chinese Journal of Emergency Medicine, 2016, 25(10):1855-1858. 2. Wang Lijuan, Lu Junzhang, Li Mingwei, Chen Gege, cow Baolong, Qu Baolin. Effects of compound Zhuye gypsum granule on the expression of COX-2 and MMP-2 mRNA and protein in acute radiation esophagitis in rabbits [J]. Medical Journal of PLA, 2017,29(05):5-8. 3. Yang Jing, Yuan Yufeng, Zhu Wenxiong, etc. Effect of Tiangui recipe on apoptosis of spermatogenic cells in rats with oligoasthenospermia induced by cyclophosphamide [J]. Chinese traditional medicines, 2019, 041(011):2785-2787. 4. Tang, Sheng-Chun, et al. "G-protein-signaling modulator 2 expression and role in a CD133 incremental cancer stem cell subset." Oncology Targets and therapy 12 (2019): 785.https://dx.doi.org/10.2147/OTT.S187670 5. [IF = 4.147] Sheng-Chun Dang et al."G-protein-signaling modulator 2 expression and role in a CD133 pancreatic cancer stem cell subset."Oncotargets Ther. 2019; 12: 785-794 |