盐酸齐拉西酮杂质A

盐酸齐拉西酮杂质A - Names and Identifiers

Name	3-(1-piperazinyl)-1,2-benzisothiazole hydrochloride
Synonyms	3-(1-Piperazinyl)-1,2-benzisot 1,2-BENZISOTHIAZOLE,3-(1-PIPERAZINYL)HCL 3-piperazinobenzisothiazole hydrochloride 3-Piperazinobenzisothiazole hydrochloride 3-(1-PIPERAZINYL)-1,2-BENZISOTHIAZOLE HCL 3-Piperazino-1,2-benzisothiazol Hydrochlorid 3-PIPERAZINYL-1,2-BENZISOTHIAZOLE HYDROCHLORIDE 3-Piperazinyl-1,2-benzisothiazole hydrochloride 3-Piperazinyl-1,2-Benzisothiazole Hydrochloride 3-(1-piperazinyl)-1,2-benzisothiaole hydrochloride 1,2-BENZISOTHIAZOLE-3-(1-PIPERAZINYL) HYDROCHLORIDE 1,2-Benzisothiazole-3-(1-piperazinyl) Hydrochloride 1-(1,2-Benzisothiazol-3-yl)piperazine hydrochloride 3-(1-piperazinyl)-1,2-benzisothiazile hydrochloride 3-(1-piperazinyl)-1,2-benzisothiazole hydrochloride 1-(1,2-BENZISOTHIAZOL-3-YL)-PIPERAZINE HYDROCHLORIDE 1,2-Benzisothiazole,3-(1-piperazinyl),hydrochloride 3-(1-Piperazinyl)-1,2-benzisothiaxole monohydrochloride 3-(1-PIPERAZINYL)-1,2-BENZISOTHIAZOLE (FOR ZIPRASIDONE) 3-(1-Piperazinyl)-1,2-benzisothiazole hydrochloride ( For Ziprasidone ) 1,2-BENZISOTHIAZOLE,3-(1-PIPERAZINYL),HYDROCHLORIDE. (PREPARATION FOR ZIPRASIDONE)
CAS	144010-02-6 87691-88-1
EINECS	604-388-8
InChI	InChI=1/C11H13N3S.ClH/c1-2-4-10-9(3-1)11(13-15-10)14-7-5-12-6-8-14;/h1-4,12H,5-8H2;1H

盐酸齐拉西酮杂质A - Physico-chemical Properties

Molecular Formula	C11H14ClN3S
Molar Mass	255.77
Boling Point	320.2°C at 760 mmHg
Flash Point	147.4°C
Vapor Presure	0.000323mmHg at 25°C
Storage Condition	Inert atmosphere,Room Temperature

盐酸齐拉西酮杂质A - Risk and Safety

Hazard Symbols	Xi - Irritant
Safety Description	24/25 - Avoid contact with skin and eyes.
HS Code	29349990
Hazard Class	IRRITANT

盐酸齐拉西酮杂质A - Reference Information

intermediate of ziprasidone

intermediate of ziprasidone: 5-(2-chloroethyl) -6-chloro-1, 3-dihydro-indol-2-(2H)-One, 5-chloroacetyl-6-chloro-1, 3-dihydro-2h-indol-2-one, 3-(1-piperazinyl)-1,2-benzisothiazole hydrochloride is a kind of atypical antipsychotic drugs, belongs to benzothiazole piperazine compounds, in vitro, this product on dopamine D2, D3, 5-HT2A, 5-HT2C, 5-HT1A, the affinity of 5-HT1D and α1 adrenoceptors is strong; The affinity for histamine H1 receptors is moderate. It has antagonistic effect on dopamine D1, D2, 5-HT2A, 5-HT1D and agonistic effect on 5-HT1A receptor. This product inhibits the reuptake of 5-HT and norepinephrine by presynaptic membrane. The mechanism of action is not clear, it may be through the combined antagonism of dopamine D2 and 5-HT2 to produce anti schizophrenia effect, its blocking intensity is similar to risperidone and haloperidol, and is stronger than olanzapine, quetiapine and clozapine, mainly used for acute or chronic, primary or recurrent schizophrenia, schizophrenia negative, positive symptoms are effective. In particular, the effect of negative symptoms is better. It can reduce hallucinations, delusions, thinking and abnormal action and other positive symptoms; But also improve the emotional monotony, the will of the sex to reduce the negative symptoms. Atypical antipsychotic drugs, also known as a new generation of antipsychotic drugs, refers to the dopamine D2 receptor blocking is weaker than the 5-HT2A receptor blocking antipsychotic drugs, such as the current clinical use of clozapine, concomitant ketones, olanzapine, quetiapine, ziprasidone and other drugs are such. Atypical antipsychotics in addition to clinical application of clozapine earlier (70 years). Atypical antipsychotics not only block dopamine D2 receptors, but also have a stronger effect of blocking 5-HT2A receptors. When blocking the midbrain-limbic pathway dopamine D2 receptors, can improve the patient's positive symptoms; When blocking the midbrain-cortical pathway on the presynaptic membrane of 5-HT2A receptors, can cause the release of dopamine, excites dopamine D1 receptor in dorsolateral prefrontal cortex, improves negative and cognitive symptoms, excites dopamine D1 receptor in medial prefrontal cortex and orbit, and improves depressive symptoms; when blocking 5-HT2A receptors on the presynaptic membrane of the substantia nigra-striatal pathway causes a deinhibitory release of dopamine, which may partially counteract the blockade of dopamine D2 receptors by the drug, so the extrapyramidal reaction is mild (long-term use is not easy to cause tardive dyskinesia); When the 5-HT2A receptor on the presynaptic membrane of the hypothalamus-infundibulum is blocked, the deinhibitory release of dopamine is caused, which partially counteracts the blockade of the dopamine D2 receptor by the drug, so that Hyperprolactinemia is not obvious.

Use

for the preparation of ziprasidone and perospirone
ziprasidone, perospirone intermediate.

Last Update：2024-04-10 22:29:57

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Changsha Changtang import and Export Co., Ltd.

Product Name: 3-Piperazinyl-1,2-benzisothiazole hydrochloride Request for quotation
CAS: 87691-88-1
Tel: +86 18942506900
Email: 492657010@qq.com
Mobile: +86 18942506900
QQ: 492657010

Wechat: +86 18942506900
WhatsApp: +86 18942506900
Linkedin: +86 18942506900

SHANGHAI ACMEC BIOCHEMICAL TECHNOLOGY CO., LTD.

Multiple SpecificationsSpot supply

Wechat: 18621343501
WhatsApp: +86-18621343501

Shanghai Macklin Biochemical Co., Ltd

Multiple SpecificationsSpot supply

Product Name: 3-Piperazinobenzisothiazole hydrochloride Visit Supplier Webpage Request for quotation
CAS: 87691-88-1
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328

WhatsApp: +86-18821248368

Shanghai Yuanye Bio-Technology Co., Ltd.

Multiple Specifications

Product Name: 3-Piperazinobenzisothiazole hydrochloride Visit Supplier Webpage Request for quotation
CAS: 144010-02-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Shanghai Worldyang Chemical Co.,Ltd.

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View History

盐酸齐拉西酮杂质A
硫丹硫酸酯标准溶液

盐酸齐拉西酮杂质A

3-(1-piperazinyl)-1,2-benzisothiazole hydrochloride

CAS: 144010-02-6;87691-88-1

Molecular Formula: C11H14ClN3S

盐酸齐拉西酮杂质A - Names and Identifiers

盐酸齐拉西酮杂质A - Physico-chemical Properties

盐酸齐拉西酮杂质A - Risk and Safety

盐酸齐拉西酮杂质A - Reference Information

Supplier List

盐酸齐拉西酮杂质A Request for Quotation

3-(1-piperazinyl)-1,2-benzisothiazole hydrochloride

CAS: 144010-02-6;87691-88-1

Molecular Formula: C11H14ClN3S

盐酸齐拉西酮杂质A - Names and Identifiers

盐酸齐拉西酮杂质A - Physico-chemical Properties

盐酸齐拉西酮杂质A - Risk and Safety

盐酸齐拉西酮杂质A - Reference Information

Supplier List

盐酸齐拉西酮杂质A