Name | Isosinensetin;3',4' ,5,7,8-pentamethoxyflavone |
Synonyms | Isosinensetin 6-Demethoxynobiletin 6-Demethoxylnobiletin 3',4',5,7,8-pentamethoxyflavon 3',4' ,5,7,8-pentaMethoxyflavone Isosinensetin3',4' ,5,7,8-pentamethoxyflavone Isosinensetin;3',4' ,5,7,8-pentamethoxyflavone 2-(3,4-Dimethoxyphenyl)-5,7,8-trimethoxy-4H-chromen-4-one 2-(3,4-Dimethoxyphenyl)-5,7,8-trimethoxy-4H-1-benzopyran-4-one |
CAS | 17290-70-9 |
Molecular Formula | C20H20O7 |
Molar Mass | 372.37 |
Density | 1.244±0.06 g/cm3(Predicted) |
Melting Point | 198-199℃ |
Boling Point | 565.3±50.0 °C(Predicted) |
Solubility | Soluble in DMSO, ethyl acetate |
Appearance | Yellow or light yellow powder |
Storage Condition | 2-8°C |
MDL | MFCD21333406 |
Physical and Chemical Properties | Yellow crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from orange peel. |
Reference Show more | 1. [IF=6.543] Wang Yue et al."Polymethoxyflavones in Citrus Regulate Lipopolysaccharide-Induced Oscillating Decay of Circadian Rhythm Genes by Inhibiting Nlrp3 Expression."Oxid Med Cell Longev. 2021;2021:8419415 2. [IF=4.35] Qian Yu et al."Aged Pericarpium Citri Reticulatae ‘Chachi’ Attenuates Oxidative Damage Induced by tert-Butyl Hydroperoxide (t-BHP) in HepG2 Cells."Foods. 2022 Jan;11(3):273 3. [IF=5.34] Dong Shao et al."Identification of the active compounds and functional mechanisms of Jinshui Huanxian formula in pulmonary fibrosis by integrating serum pharmacochemistry with network pharmacology."PHYTOMEDICINE. 2022 Jul;102:154177 |
biological activity | Isosinensetin is a methoxyflavonoid extracted from green peel, which has an inhibitory effect on p-glycoprotein (P-gp) in MDR1-MDCKII cells. |
target | P-glycoprotein |
chemical properties | yellow crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from orange peel. |
use | used for content determination/identification/pharmacological experiments, etc. |