叠氮八聚乙二醇琥珀酰亚胺
Azido-PEG8-NHS ester
CAS: 1204834-00-3
Molecular Formula: C23H40N4O12
叠氮八聚乙二醇琥珀酰亚胺 - Names and Identifiers
叠氮八聚乙二醇琥珀酰亚胺 - Physico-chemical Properties
| Molecular Formula | C23H40N4O12 |
| Molar Mass | 564.5833 |
| Appearance | solid or viscous liquid |
| Storage Condition | -20°C |
| In vitro study | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. |
叠氮八聚乙二醇琥珀酰亚胺 - Reference Information
| biological activity | Azido-PEG8-NHS ester is a degradable (cleavable) 8-unit PEG-containing ADC linker that can be used to synthesize antibody-coupled drugs (ADC). Azido-PEG8-NHS ester is also a PROTAC linker, belonging to the PEG and Alkyl/ether classes, which can be used to synthesize PROTAC molecules. |
| target | PEGs Alkyl/ether Cleavable |
| in vitro study | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. |
Last Update：2024-04-09 20:52:54
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