反式-4-(4-氟苯基)吡咯烷-3-羧酸乙酯 - Names and Identifiers
反式-4-(4-氟苯基)吡咯烷-3-羧酸乙酯 - Physico-chemical Properties
反式-4-(4-氟苯基)吡咯烷-3-羧酸乙酯 - Introduction
ethyl trans-4-(4-fluorophenyl)pyrrolidine-3-carboxylate, also known as acetyltrans-4-(4-fluorophenyl)pyrrolidine-3-carboxylate, is an organic compound. The following is a detailed description of its nature, use, formulation and safety information:
Nature:
-Appearance: Colorless liquid or solid.
-Solubility: Soluble in organic solvents, such as ethanol and dimethylformamide.
-molecular formula: C and H and H and NO and F
-Molecular weight: 247.277g/mol
-Melting point: 50-54 ° C
-Boiling point: 314-315 ° C
Use:
- ethyl trans-4-(4-fluorophenyl)pyrrolidine-3-carboxylate is a unique organic compound, often used as a pharmaceutical intermediate for the synthesis of various drugs, such as antidepressants and neurotransmitter-related drugs.
Method:
ethyl trans-4-(4-fluorophenyl)pyrrolidine-3-carboxylate is prepared as follows:
1. First, ethyl acetate and trans-4-(4-fluorophenyl) pyrrolidine-3-carboxylic acid are reacted by a transesterification reaction (for example, using hydrochloric acid as a catalyst), ethyl trans-4-(4-fluorophenyl) pyrrolidine-3-acetate is produced.
2. Next, using aluminum acetate (AlCl) as catalyst, under the protection of nitrogen, the condensation reaction of acid and olefin was used to obtain ethyl trans-4-(4-fluorophenyl)pyrrolidine-3-carboxylate.
Safety Information:
- ethyl trans-4-(4-fluorophenyl)pyrrolidine-3-carboxylate irritating and corrosive.
-Wear appropriate personal protective equipment, such as gloves and safety glasses, when handling the compound.
-Avoid direct skin contact or inhalation of gases or vapors.
-When handling the compound, follow laboratory safety procedures and maintain good ventilation.
-If ingested or inhaled, seek medical attention immediately.
Please note that this is general information only. Careful reference should be made to specific chemical specifications and the advice of professionals working in the field before the actual application and handling of the compound.
Last Update:2024-04-09 21:01:54