Introduction | carbomer is a polymer of acrylic acid crosslinked with allyl sucrose or Pentaerythritol, it was first produced by G00drich company in the United States under the trade name carbop01. Chinese Pharmacopoeia 2005 edition has been included. This product is a loose white powder, acidic, hygroscopic and special odor, soluble in water, ethanol, glycerol. The molecule contains 56% to 58% of a carboxyl group, and thus is weakly acidic. When the carbomer is dispersed in water, the crimped polymer expands and expands in volume due to the repulsive effect between the negative charges generated by the ionization of the carboxyl groups. The pH of the 0.5% aqueous dispersion was 2.7-3.5. The 1% aqueous dispersion can be neutralized with an alkaline substance to form a gel. The concentration of the aqueous dispersion is usually 0.1% to 3.0%. |
pharmacological action | This product is a kind of hydrogel, composed of solid phase (I. E. Carbomer) and liquid phase (water) as Dispersion Medium composition. Carbomer is a polyacrylic acid polymer crosslinked with pentaerythritol allyl ether or sucrose. Based on its hydrogel properties, this product can adhere to the surface of the cornea and can retain fluid. The structure of the gel is destroyed by the salt in the tear fluid, releasing water from it. |
Application | The main function of carbomer is thickening, suspension, emulsification, etc. It can be used as a gel, adhesive, coating materials, Rheology Modifiers (moisturizers, lubricants, suspending agents, stabilizers), etc., are widely used, especially in new drug delivery systems with greater application prospects. At home and abroad have been widely used. |
Overview | carbomer is a polymer of acrylic acid crosslinked with allyl sucrose or Pentaerythritol, it was first produced by G00drich company in the United States under the trade name carbop01. Chinese Pharmacopoeia 2005 edition has been included. |
purpose | is mainly used as controlled-release drugs made of sustained-release materials, topical drug as carrier matrix |