化合物CAPIVASERTIB
4-Piperidinecarboxamide, 4-amino-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-
CAS: 1143532-39-1
Molecular Formula: C21H25ClN6O2
化合物CAPIVASERTIB - Names and Identifiers
化合物CAPIVASERTIB - Physico-chemical Properties
| Molecular Formula | C21H25ClN6O2 |
| Molar Mass | 428.92 |
| Density | 1.381 |
| Melting Point | 161-164°C |
| Solubility | DMSO (Slightly), Methanol (Slightly) |
| Appearance | Solid |
| Color | Off-White to Pale Beige |
| pKa | 13.93±0.50(Predicted) |
| Storage Condition | Refrigerator |
| In vitro study | AZD5363 is a potent inhibitor of Akt, inhibiting Akt1, Akt2 and Akt3 with IC50 of 3 nM, 8 nM and 8 nM, respectively. The activation of PIK3CA mutation, the loss or inactivation of the tumor suppressor gene PTEN, or the amplification of HER2 all have a significant relationship with AZD5363. Furthermore, a correlation between the RAS mutational status of the cell lines and the anti-azd5363 can also be seen. AZD5363 inhibited phosphorylation of AKT substrates in cells with a titer of about 0.3~0.8 μm. AZD5363 inhibited cell proliferation in 41 of 182 solid and hematologic tumor cell lines with a titer of <3 μm. |
| In vivo study | AZD5363 was orally administered to nude mice at a dose of 100,300 mg/kg to reduce the phosphorylation of PRAS40, GSK3β, and S6 in the transplanted tumor of BT474c in a dose-and time-dependent manner, it also reversibly increases blood glucose concentration and reduces 2 [ |
化合物CAPIVASERTIB - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.331 ml | 11.657 ml | 23.314 ml |
| 5 mM | 0.466 ml | 2.331 ml | 4.663 ml |
| 10 mM | 0.233 ml | 1.166 ml | 2.331 ml |
| 5 mM | 0.047 ml | 0.233 ml | 0.466 ml |
Last Update：2024-01-02 23:10:35
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View History
化合物CAPIVASERTIB
Benzyl 2-aminobenzoate
(Octadecadienoic acid)dipolymer
(R)-[(RUCL(T-BINAP))2(Μ-CL)3[NH2ME2]
5-溴-6-氯-3-吲哚基 磷酸对甲苯铵盐
DIENDO-3-AMINO-BICYCLO[2.2.1]HEPT-5-ENE-2-CARBOXYLIC ACID ETHYL ESTER HYDROCHLORIDE
Α-ETHYLAMINOPENTIOPHENONE (HYDROCHLORIDE)
1-乙基-4-碘-3-甲基-1H-吡唑-5-甲酸乙酯
二硝基硫酸二氢化铂
茴香酸对羟基苯乙酯对照品
Benzyl 2-aminobenzoate
(Octadecadienoic acid)dipolymer
(R)-[(RUCL(T-BINAP))2(Μ-CL)3[NH2ME2]
5-溴-6-氯-3-吲哚基 磷酸对甲苯铵盐
DIENDO-3-AMINO-BICYCLO[2.2.1]HEPT-5-ENE-2-CARBOXYLIC ACID ETHYL ESTER HYDROCHLORIDE
Α-ETHYLAMINOPENTIOPHENONE (HYDROCHLORIDE)
1-乙基-4-碘-3-甲基-1H-吡唑-5-甲酸乙酯
二硝基硫酸二氢化铂
茴香酸对羟基苯乙酯对照品