伊马替尼杂质甲基甲烷磺酸盐
Methyl methanesulfonate
CAS: 66-27-3
Molecular Formula: C2H6O3S
伊马替尼杂质甲基甲烷磺酸盐 - Names and Identifiers
| Name | Methyl methanesulfonate |
| Synonyms | MMS CB 1540 as-dimethylsulfite as-dimethylsulphite as-Dimethyl sulphite Methyl methanesulfonate METHYL METHANESULFONATE METHYLMETHANE SULPHONATE METHYL METHANESULPHONATE Methanesulfonic acid methyl ester METHANESULFONIC ACID METHYL ESTER |
| CAS | 66-27-3 |
| EINECS | 200-625-0 |
| InChI | InChI=1/C2H6O3S/c1-5-6(2,3)4/h1-2H3 |
| InChIKey | MBABOKRGFJTBAE-UHFFFAOYSA-N |
伊马替尼杂质甲基甲烷磺酸盐 - Physico-chemical Properties
| Molecular Formula | C2H6O3S |
| Molar Mass | 110.13 |
| Density | 1.3g/mLat 25°C(lit.) |
| Melting Point | 20°C |
| Boling Point | 202-203°C(lit.) |
| Flash Point | 220°F |
| Water Solubility | 200 g/L (20 ºC) |
| Solubility | 200g/l |
| Vapor Presure | 0.8 hPa (59 °C) |
| Appearance | Liquid |
| Color | Colorless to pale yellow |
| Merck | 14,6097 |
| BRN | 1098586 |
| Storage Condition | Store below +30°C. |
| Stability | Stable. Combustible. Incompatible with strong oxidizing agents, strong acids, strong bases. |
| Refractive Index | n20/D 1.414(lit.) |
伊马替尼杂质甲基甲烷磺酸盐 - Risk and Safety
| Hazard Symbols | T - Toxic |
| Risk Codes | R45 - May cause cancer R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. R68 - Possible risk of irreversible effects |
| Safety Description | S53 - Avoid exposure - obtain special instructions before use. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| UN IDs | UN 2810 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | PB2625000 |
| FLUKA BRAND F CODES | 21 |
| TSCA | Yes |
| HS Code | 2905 19 00 |
| Hazard Class | 6.1(b) |
| Packing Group | III |
| Toxicity | LD50 orally in Rabbit: 225 mg/kg |
伊马替尼杂质甲基甲烷磺酸盐 - Reference Information
| (IARC) carcinogen classification | 2A (Vol. 7, Sup 7, 71) 1999 |
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| genotoxicity | mesylate is a genotoxic impurity with a limit of 1.5g/d. 1 The daily dose is 800 mg, accordingly, the limit of MMS and EMS must not be more than 1.875G/G. Preclinical studies of some mesylate esters have found that these mesylate esters can directly react with biological macromolecules (DNAs,RNAs and proteins) by alkylation, which may lead to DNA mutation, carcinogenic effect and teratogenic effect. |
| varieties of sulfonic acid esters | methanesulfonic acid, benzene methane sulfonic acid and other sulfonate substances and trace amounts of lower alcohols in the synthesis reaction to generate alkyl sulfonate, such as methyl Methane Sulfonate (MMS), Ethyl Methane Sulfonate (EMS), isopropyl Methane Sulfonate (IMS), N-butyl methanesulfonate (NBMS), as well as aryl sulfonates such as methyl benzenesulfonate (MBS), ethyl benzenesulfonate (EBS), p-toluenesulfonate (MP-TS), which can alkylate with DNA, thus, it may become a cause of cancer, so it is very important to control the threshold of toxicological concern (TTC) level of such impurities in drugs, the European EMA has published a maximum intake of genotoxic impurities of 1.5 μg/d. |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 21:04:16
Supplier List
Spot supply
Product Name: Methyl methanesulfonate Request for quotationCAS: 66-27-3
Tel: +86-18721521379
Email: 18721521379@163.com
Mobile: +86-18721521379
Wechat: 18721521379
Spot supply
Product Name: Methyl methanesulfonate Request for quotationCAS: 66-27-3
Tel: +86-17551318830
Email: r@reformchem.com
Mobile: +86-17551318830
QQ: 3785839865
Wechat: chemical6666
Multiple SpecificationsSpot supply
Product Name: Methyl methanesulfonate (Standard) Visit Supplier Webpage Request for quotationCAS: 66-27-3
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: Methyl methanesulfonate Visit Supplier Webpage Request for quotationCAS: 66-27-3
Tel: +86 0571-86722205
Email: sales@chinaskyrun.com
Mobile: +8618958170122
QQ: 2531159185
Wechat: chinaskyrun
Spot supply
Product Name: Methyl methanesulfonate Visit Supplier Webpage Request for quotationCAS: 66-27-3
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: Methyl methanesulfonate Visit Supplier Webpage Request for quotationCAS: 66-27-3
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: Methyl methanesulfonate Request for quotationCAS: 66-27-3
Tel: +86-18721521379
Email: 18721521379@163.com
Mobile: +86-18721521379
Wechat: 18721521379
Spot supply
Product Name: Methyl methanesulfonate Request for quotationCAS: 66-27-3
Tel: +86-17551318830
Email: r@reformchem.com
Mobile: +86-17551318830
QQ: 3785839865
Wechat: chemical6666
Multiple SpecificationsSpot supply
Product Name: Methyl methanesulfonate (Standard) Visit Supplier Webpage Request for quotationCAS: 66-27-3
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: Methyl methanesulfonate Visit Supplier Webpage Request for quotationCAS: 66-27-3
Tel: +86 0571-86722205
Email: sales@chinaskyrun.com
Mobile: +8618958170122
QQ: 2531159185
Wechat: chinaskyrun
Spot supply
Product Name: Methyl methanesulfonate Visit Supplier Webpage Request for quotationCAS: 66-27-3
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: Methyl methanesulfonate Visit Supplier Webpage Request for quotationCAS: 66-27-3
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
View History