Molecular Formula | C10H12N2O3 |
Molar Mass | 208.21 |
Density | 1.343±0.06 g/cm3(Predicted) |
Boling Point | 466.6±45.0 °C(Predicted) |
Solubility | 0.5M HCl |
Appearance | Faint Yellow to Yellow-Green powder |
Storage Condition | 2-8℃ |
Physical and Chemical Properties | Bioactive D-kynurenine is a metabolite of D-tryptophan, which can be used as a biological precursor of hydrouric acid (KYNA) and 3-hydroxykynurenine (3-hydroxykynurenine). D-kynurenine are agonists of G protein-coupled receptor GPR109B and D-kynurenine are substrates for D-amino acid oxidase fluorescence analysis. D-kynurenine promotes the transformation of epithelial cells into mesenchymal cells by activating aromatic hydrocarbon receptors (AHR). |
Downstream Products | L-KYNURENINE |
boiling point | 466.6±45.0 °C(Predicted) |
density | 1.343±0.06 g/cm3(Predicted) |
storage conditions | Sealed in dry,2-8°C |
acidity coefficient (pKa) | 2.21±0.23(Predicted) |
target
Human Endogenous Metabolite
in vitro study
D-kynurenine (10, 40, 60, and 100 µM) positively regulates the metastasis of 95D cells, a lung cancer cell line, which is reduced upon siRNAAhr treatment. Significant enhancement VIM expression was detected in the presence of D-kynurenine(10 and 40 µM). 10 µM D-kynurenine markedly attenuates E-cadherin level. 10 µM D-kynurenine-mediated changes of VIM and E-cadherin are substantially attenuated on siRNAAhr treatment as well. The evidences-10/40 µM D-kynurenine-induced up-regulation of CYP1A1, 10 µM D-kynurenine-induced increase of nuclear transfer of Ahr, and 10/40/60/100 µM D-kynurenine-induced enhancement of DER-luciferase activity-indicated that D-kynurenine Is capable of activating Ahr in fact.