Name | tiotixene |
Synonyms | tiotixene TIOTHIXENE thiothixene THIOTHIXENE cis-Tiotixene Thiothixene (250 mg) N,N-DIMETHYL-9-[3-(4-METHYL-1-PIPERAZINYL)PROPYLIDENE]THIOXANTHENE-2-SULFONAMIDE N,N-dimethyl-9-(3-(4-methylpiperazin-1-yl)propylidene)thioxanthene-2-sulphonamide (Z)-N,N-Dimethyl-9-[3-(4-methyl-1-piperazinyl)propylidene]-9H-thioxanthene-2-sulfonamide N,N-Dimethyl-9-[(Z)-3-(4-methyl-1-piperazinyl)propylidene]-9H-thioxanthene-2-sulfonamide (9Z)-N,N-dimethyl-9-[3-(4-methylpiperazin-1-yl)propylidene]-9H-thioxanthene-2-sulfonamide cis-Thiothixene, N,N-Dimethyl-9-[3-(4-methyl-1-piperazinyl)propylidene]thioxanthene-2-sulfonamide |
CAS | 3313-26-6 |
EINECS | 227-001-0 |
InChI | InChI=1/C23H29N3O2S2/c1-24(2)30(27,28)18-10-11-23-21(17-18)19(20-7-4-5-9-22(20)29-23)8-6-12-26-15-13-25(3)14-16-26/h4-5,7-11,17H,6,12-16H2,1-3H3/b19-8- |
Molecular Formula | C23H29N3O2S2 |
Molar Mass | 443.63 |
Density | 1.269±0.06 g/cm3(Predicted) |
Melting Point | 147~152℃ |
Boling Point | 599.0±60.0 °C(Predicted) |
Flash Point | 316.1°C |
Solubility | Chloroform (Slightly), Methanol (Slightly) |
Vapor Presure | 2.62E-14mmHg at 25°C |
Appearance | neat |
Color | White to Off-White |
pKa | pKa 7.67 (Uncertain);7.97 (Uncertain) |
Storage Condition | 2-8°C |
Stability | Light Sensitive |
Refractive Index | 1.643 |
In vitro study | (Z)-Thiothixene is capable of promoting cell survival and/or plasticity, and/or inhibiting cell death, especially when a toxic agent is exposed to the cells, including neuronal cells. (Z)-Thiothixene is a Z (cis) isomer of thiothixene, as well as synthetic precursor and degradant. |
Hazard Symbols | Xn - Harmful |
Risk Codes | 22 - Harmful if swallowed |
RTECS | XO1420000 |
HS Code | 2935904000 |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 2.254 ml | 11.271 ml | 22.541 ml |
5 mM | 0.451 ml | 2.254 ml | 4.508 ml |
10 mM | 0.225 ml | 1.127 ml | 2.254 ml |
5 mM | 0.045 ml | 0.225 ml | 0.451 ml |
overview | tivothiazepam (Tiotixene) is an antipsychotic drug with thioanthracene structure, which has been widely used in chronic schizophrenia patients abroad. it has been successfully trial-produced by Shanghai no 1 pharmaceutical factory in China and has not yet been used clinically. Kinetic studies of this capsule in rabbits have been reported. |
use | has strong antipsychotic effect. It is used for the symptoms of apathy, loneliness, and decreased initiative of acute and chronic psychosis; it is also used for anxiety. Tivothione has a weak anti-hallucinatory and delusional effect, and has no sedative and hypnotic effect. It has an exciting effect on the behavioral withdrawal, reduced initiative and apathy of chronic schizophrenia. It also has curative effect on agitation or depression of affective psychosis, hallucinations and delusions of acute schizophrenia, and the effect is better than that of chlorprothiton. In addition, Tivothione has anti-vomiting and slight antihypertensive and antispasmodic effects. |
Pharmacological effects | Tivorthiazepam is a thioxamine with a piperazine side chain. The effect is similar to that of chlorpromazine. The sedative effect is weak, but the antipsychotic effect is stronger than chlorpromazine, and it has anti-anxiety and anti-depression effects. The efficacy of tivorthione is better than that of chlorprothione. |
pharmacokinetics | oral absorption is good, and blood drug peak can be reached in 1~3 hours. T1/2 is 34h. There was still a high blood concentration 24h after receiving a single dose. After 8 weeks of medication, the blood drug concentration decreased rapidly, but still maintained a good dose-effect relationship, so it is considered that the drug can be administered once a day. |
biological activity | (z)-Thiothixene is an antagonist of serotonergic receptor, from patent US 20150141345 A1. |