r-818
Flecainide Acetate
CAS: 54143-56-5
Molecular Formula: C19H24F6N2O5
r-818 - Names and Identifiers
r-818 - Physico-chemical Properties
| Molecular Formula | C19H24F6N2O5 |
| Molar Mass | 474.39 |
| Melting Point | 145-147℃ |
| Water Solubility | Soluble in dilute acetic acid, dimethyl sulfoxide, ethanol, methanol and water. |
| Solubility | Soluble in water and in anhydrous ethanol. It is freely soluble in dilute acetic acid and practically insoluble in dilute hydrochloric acid. |
| Appearance | neat |
| Color | White |
| Storage Condition | 2-8°C |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 1 month. |
| In vitro study | Flecainide is a class 1C antiarrhythmic drug especially used for the management of supraventricular arrhythmia. Flecainide works by blocking the Nav1.5 sodium channel in the heart, causing prolongation of the cardiac action potential. in vitro: Under the current-clamp condition, flecainide (1-100 microM) prolonged the action potential duration at both the early and the late phases of repolarization in a concentration-dependent manner without affecting the resting membrane potential [1]. At a holding potential (HP) of -120 mV, flecainide use-dependently blocked WT and G1306E I(Na) equally but was more potent on R1448C channels. For WT, the extent of block depended on a holding voltage more negative than the activation threshold, being greater at -90 mV as compared to -120 and -180 mV [2]. in vivo: Flecainide (80-130 mg/m(2) orally) resulted in termination of the tachycardia in all 8 patients. Acute pharmacological termination of arrhythmia occurred with oral flecainide loading in 1 and temporarily with intravenous esmolol loading in 1 patient. Adjuvant therapy in form of propranolol was used in 5 and digoxin in 2 [3]. |
r-818 - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. R63 - Possible risk of harm to the unborn child |
| Safety Description | S22 - Do not breathe dust. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S46 - If swallowed, seek medical advice immediately and show this container or label. |
| UN IDs | 3249 |
| WGK Germany | - |
| RTECS | CV5792550 |
| HS Code | 2933399090 |
| Hazard Class | 6.1(b) |
| Packing Group | III |
r-818 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.108 ml | 10.54 ml | 21.08 ml |
| 5 mM | 0.422 ml | 2.108 ml | 4.216 ml |
| 10 mM | 0.211 ml | 1.054 ml | 2.108 ml |
| 5 mM | 0.042 ml | 0.211 ml | 0.422 ml |
Last Update：2024-01-02 23:10:35
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