Name | p-Ethynylphenylalanine |
Synonyms | p-Ethynylphenylalanine 4-Ethynyl-L-phenylalanine L-Phenylalanine, 4-ethynyl- 4-Ethynyl-L-phenylalanine HCl |
CAS | 278605-15-5 |
Molecular Formula | C11H12ClNO2 |
Molar Mass | 225.67148 |
Appearance | Solid |
Storage Condition | 2-8°C,密封,干燥 |
In vitro study | p-Ethynylphenylalanine selectively and reversibly inhibits the biosynthesis of serotonin. p-Ethynylphenylalanine has a low affinity for various recombinant 5-HT receptors (5-HT 1 , 5-HT 2 , 5-HT 4 , 5-HT 5 , 5-HT 6 , and 5-HT 7 ). |
biological activity | p-Ethynylphenylalanine (4-ethyl-l-phenylalanine) is a highly efficient, selective, reversible, A competitive tryptophan hydroxylase (TPH) inhibitor with a Ki of 32.6 μm. |
Target | Ki: 32.6 μm (TPH) |
Animal Model: | Male Sprague-Dawley rats (200 g) |
Dosage: | 30 mg/kg |
Administration: | Intraperitoneal injection |
Result: | Decreased in 5-HT and 5-HIAA levels in the rat midbrain. |