Molecular Formula | C12H15N3O
|
Molar Mass | 217.27 |
Density | 1.20±0.1 g/cm3 (20 ºC 760 Torr) |
Melting Point | 50-53°C |
Boling Point | 324.5±45.0 °C(Predicted) |
Solubility | Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly) |
Appearance | Solid |
Color | Pale Yellow to Brown Oil to |
pKa | 4.76±0.20(Predicted) |
Storage Condition | -20°C Freezer |
Physical and Chemical Properties | Oillike liquid. |
Use | For inspection |
In vitro study | Metamizole is a prodrug which, at room temperature and in an atmosphere with oxygen, is spontaneously, nonenzymatically converted to 4-Methylamino antipyrine. Subsequently, the N-methyl side chain of 4-Methylamino antipyrine is oxidized to yield 4-formylaminoantipyrine, which is further converted to 4-aminoantipyrine. Metamizole in aqueous solution and in the presence of oxygen consists of a group of several pyrazolone derivatives of which 4-Methylamino antipyrine is pharmacologically the most important. |
In vivo study | The aim of this study is to assess the pharmacokinetics of its active metabolites 4-Methylamino antipyrine in male piglets after a single intramuscular injection of Metamizole. Eight healthy male piglets are administered Metamizole (100 mg/kg) intramuscularly. 4-Methylamino antipyrine plasma concentrations are quantitatively detectable from 0.25 to 48 h. The average maximum concentrations of 4-Methylamino antipyrine is of 47.59 mg/mL. The average half-lives is 8.57 h for 4-Methylamino antipyrine. |