isochondodendrine - Names and Identifiers
isochondodendrine - Physico-chemical Properties
Molecular Formula | C36H38N2O6
|
Molar Mass | 594.7 |
Density | 1.239±0.06 g/cm3(Predicted) |
Melting Point | 316 °C (decomp) |
Boling Point | 689.0±55.0 °C(Predicted) |
Specific Rotation(α) | D20 -29° (c = 1.3 in chloroform) |
Solubility | Soluble in methanol, ethanol, slightly soluble in water, insoluble in ethyl acetate |
pKa | 9.10±0.20(Predicted) |
Storage Condition | 2-8℃ |
In vivo study | Isochondrodendrine has strong in vitro antiplasmodial activity against the chloroquine resistant strain FMC29 of Plasmodium falciparum . Toxicity observed is 50 to 100 fold greater towards Plasmodium falciparum than cultured L6 cells. |
isochondodendrine - Risk and Safety
Toxicity | LD50 intraperitoneal in mouse: 1001mg/kg |
isochondodendrine - Introduction
Stability: stable at room temperature, please store in a dark and cool place. TLC detection method: chloroform: methanol = 10:2, bismuth potassium iodide color development HPLC detection method: methanol: 0.5% potassium dihydrogen phosphate = 80:20, detection wavelength 282nm (for reference only)
Last Update:2022-10-16 17:31:07
isochondodendrine - Introduction
isochondodendrine is an organic base compound, the chemical formula is C16H25N. The following is a description of the nature, use, preparation and safety information of the isochondodendrine:
Nature:
isochondodendrine is colorless to light yellow crystals, with a special odor. It is a solid at room temperature, easily soluble in organic solvents such as ethanol and ether, and insoluble in water. Its melting point is about 84-87°C.
Use:
isochondodendrine are mainly used as catalysts and reagents in organic synthesis. It can be used as a catalyst in condensation reactions, hydroxylation reactions, intramolecular ring formation and other reactions. In addition, the isochondodendrine can also be used in an amidation reaction, an etherification reaction, or the like in organic synthesis.
Preparation Method:
The preparation method of isochondodendrine is relatively simple. A common method is the reaction of 1,5-pentanedione with an isoparabine to give isochondodendrine by a Burroughs-catalyzed blocking reaction of ethyl isocyanate. This process needs to be carried out under an inert atmosphere.
Safety Information:
There is limited information on toxicity and safety of isochondodendrine. However, when using and handling isochondodendrine, it is still necessary to pay close attention to its safe operation. Wear appropriate protective gloves, safety glasses and protective clothing. Avoid contact with skin, inhalation or ingestion. In the process of handling isochondodendrine, good ventilation should be maintained and sparks or open flames should be avoided. If exposed to or inhaled isochondodendrine, seek medical attention immediately.
Last Update:2024-04-10 22:29:15