faverin50
Fluvoxamine maleate
CAS: 61718-82-9
Molecular Formula: C19H25F3N2O6
faverin50 - Names and Identifiers
| Name | Fluvoxamine maleate |
| Synonyms | Fevarin du23000 DU23000 Luvox CR SME 3110 faverin50 UNII-5LGN83G74V FLUVOXAMINE MALEATE Fluvoxamine maleate 5-methoxy-4'-trifluoromethylvalerophenone(e)-o-2-aminoethyloximemonomaleate 1-pentanone,5-methoxy-1-(4-(trifluoromethyl)phenyl)-,o-(2-aminoethyl)oxime,( 5-Methoxy-4'-trifluoromethylvalerophenone (E)-O-2-aminoethyloxime monomaleate (E)-5-methoxy-1-[4-(trifluoromethyl)phenyl]-O-(2-aminoethyl)oxime-1-pentanone (E)-5-METHOXY-1-[4-(TRIFLUOROMETHYL)PHENYL]-1-PENTANONE-O-(2-AMINOETHYL)OXIME MALEATE Fluvoxamine maleate,(E)-5-Methoxy-1-[4-(trifluoromethyl)phenyl]-1-pentanone-O-(2-aminoethyl)oxime maleate |
| CAS | 61718-82-9 |
| EINECS | 612-212-6 |
| InChI | InChI=1/C15H21F3N2O2.C4H4O4/c1-21-10-3-2-4-14(20-22-11-9-19)12-5-7-13(8-6-12)15(16,17)18;5-3(6)1-2-4(7)8/h5-8H,2-4,9-11,19H2,1H3;1-2H,(H,5,6)(H,7,8)/b20-14+;2-1- |
| InChIKey | LFMYNZPAVPMEGP-PIDGMYBPSA-N |
faverin50 - Physico-chemical Properties
| Molecular Formula | C19H25F3N2O6 |
| Molar Mass | 434.41 |
| Melting Point | 120-121.5 °C |
| Boling Point | 370.6 °C at 760 mmHg |
| Flash Point | 9℃ |
| Solubility | DMSO 87 mg/mL Water <1 mg/mL Ethanol 87 mg/mL |
| Appearance | solid |
| Color | White to Off-White |
| Merck | 14,4219 |
| Storage Condition | 2-8°C |
| MDL | MFCD00269809 |
| Use | A SR inhibitor which binds to the 5-HT transporter. |
| In vitro study | Fluvoxamine increases the levels of [5-HT] in the prefrontal cortex and thalamus of rats and also increases the levels of [DA] in the striatum. Fluvoxamine maleate improves tactile allodynia through spinal 5-HT 2A/2C receptors, acting by acting on receptors or neurons of 5-HT. |
| In vivo study | Fluvoxamine maleate also demonstrated antinociception in a dose-dependent manner in the paw stress test in non-ligated mice. Fluvoxamine maleate also induced an antinociceptive effect of the acute paw stress test, and this effect was antagonized by the 5-HT3 receptor antagonist granisetron. In the rat hippocampal medial prefrontal cortex (mPFC), Fluvoxamine(10 and 30 mg/kg, I. P.) enhanced hippocampal-mPFC pathway synaptic potency in a dose-dependent manner. In the hippocampal CA1 region of anesthetized rats, Fluvoxamine(10 and 30 mg/kg, I. P.) inhibited long-term potentiation (LTP). Fluvoxamine(30 mg/kg, I. P.) induced complete reversal of LTP for 5-HT(1A) receptor antagonist NAN-190(0.5 mg/kg, I. P.) but not 5-HT(4) the receptor antagonist GR113808(20 mg/rat, intraventricular injection) and 5-HT (7) receptor antagonist DR4004(10 mg/rat, intraventricular injection) were affected. Fluvoxamine maleate potentiates the response to norepinephrine in isolated rat vas deferens incubated in a Krebs-Henseleit solution. Fluvoxamine maleate and Fluoxetine hydrochloride inhibited the induction of contraction of isolated rat uterus preparations by potassium ions with IC50 of 3.99 μm and 18.2 μm, respectively. |
faverin50 - Risk and Safety
| Risk Codes | R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S36 - Wear suitable protective clothing. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S27 - Take off immediately all contaminated clothing. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| UN IDs | UN1230 - class 3 - PG 2 - Methanol, solution |
| WGK Germany | 3 |
| RTECS | SA9230000 |
| HS Code | 29280000 |
faverin50 - Introduction
Fluvoxamine maleate is a selective serotonin reuptake inhibitor (SSRI).
Last Update：2022-10-16 17:27:11
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Multiple SpecificationsSpot supply
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Product Name: Fluvoxamine maleate Visit Supplier Webpage Request for quotationCAS: 61718-82-9
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QQ: 2881950922
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Tel: +86-18821248368
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View History
faverin50
Pratensein 7-O-glucopyranoside
29649-20-5
2-(3,4-二氯苯基)-2-甲基丙腈
4-Acetyl-5,6-dihydro-3-methyl-4H-1,4-thiazine-2-carboxylic acid methyl ester
TIMTEC-BB SBB006659
1-[2-(CHLOROMETHYL)BENZYL]-1H-1,2,4-TRIAZOLE
17334-50-8
111237-01-5
2-METHYL-IMIDAZO[1,2-A]PYRIDINE-3-CARBALDEHYDE
Pratensein 7-O-glucopyranoside
29649-20-5
2-(3,4-二氯苯基)-2-甲基丙腈
4-Acetyl-5,6-dihydro-3-methyl-4H-1,4-thiazine-2-carboxylic acid methyl ester
TIMTEC-BB SBB006659
1-[2-(CHLOROMETHYL)BENZYL]-1H-1,2,4-TRIAZOLE
17334-50-8
111237-01-5
2-METHYL-IMIDAZO[1,2-A]PYRIDINE-3-CARBALDEHYDE