Molecular Formula | C10H13N5O4 |
Molar Mass | 267.24 |
Melting Point | 205-207°C(lit.) |
Storage Condition | −20°C |
MDL | MFCD00064342 |
Hazard Symbols | T - Toxic |
Risk Codes | 25 - Toxic if swallowed |
Safety Description | 45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
UN IDs | UN 2811 6.1 / PGIII |
WGK Germany | - |
Overview | antisense technology is based on the principle of base complementarity, the technology of inhibiting or blocking gene expression with specific DNA or RNA fragments synthesized by artificial synthesis or organism is a new method of drug development. The synthesis of oligomeric α-uracil nucleotides was first reported by debarrett et al. in 1990 and demonstrated that it prevents non-specific degradation by a variety of proteases. An important monomer of the construction of the alpha configuration of the oligonucleotide is the alpha nucleoside. For the synthesis of Alpha nucleosides, two methods have been reported in the literature. One method uses acyl-protected sugar E as a raw material, and obtains compound F by coupling four different (or protected) bases under Silyl-Hilbert-Johnson reaction conditions, the product Alpha nucleoside was obtained after deprotection of compound F. |