acivicine
Acivicin
CAS: 42228-92-2
Molecular Formula: C5H7ClN2O3
acivicine - Names and Identifiers
acivicine - Physico-chemical Properties
| Molecular Formula | C5H7ClN2O3 |
| Molar Mass | 178.57 |
| Density | 1.85±0.1 g/cm3(Predicted) |
| Melting Point | >200°C (dec.) |
| Boling Point | 341.6±48.0 °C(Predicted) |
| Water Solubility | Soluble in water at 10mg/ml with warming |
| Solubility | H2O: soluble10mg/mL (warmed) |
| Appearance | White solid. |
| Color | white to beige |
| pKa | 2.02±0.10(Predicted) |
| Storage Condition | 2-8°C |
| Stability | Hygroscopic |
| In vitro study | Acivicin (AT-125; 0.1-50 μM; 5 days) has an IC 50 of 0.7 μM in human HepG2 cells. |
| In vivo study | Acivicin (AT-125; 5 mg/kg; IP; twice weekly) reduces urinary γ-GT by 70-78%. Animal Model: Male pigmented Long-Evans rats weighed between 250 g and 300 g exposed to Toluene Dosage: 5 mg/kg Administration: IP; twice weekly (monday and wednesday) Result: Reduced urinary γ-GT by 70-78%. |
acivicine - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | 20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. |
| Safety Description | 36 - Wear suitable protective clothing. |
| UN IDs | 3172 |
| WGK Germany | 3 |
| RTECS | NY2103000 |
| Hazard Class | 6.1(b) |
| Packing Group | III |
acivicine - Reference Information
| Biological activity | Acivicin (AT-125) is a natural product produced by Streptomyces suis and is a γ-glutamyl transpeptidase (GGT) inhibitor. Acivicin can penetrate the blood-brain barrier and have anti-cancer and anti-parasitic properties. |
| Target | γ-glutamyl transpeptidase |
| in vitro study | Acivicin (AT-125; 0.1-50 μM; 5 days) has an IC 50 of 0.7 μM in human HepG2 cells. |
| in vivo study | Acivicin (AT-125; 5 mg/kg; IP; Wice weekly) reduces urinary γ-GT by 70-78%. Animal Model: Male pigmented Long-Evans rats weighed between 250 g and 300 g exposed to Toluene Dosage: 5 mg/kg Administration: IP; Wice weekly (Monday and Wednesday) Result: reduced urinary γ-GT by 70-78%. |
| Animal Model: | Male pigmented Long-Evans rats weighed between 250 g and 300 g exposed to Toluene |
| Dosage: | 5 mg/kg |
| Administration: | IP; twice weekly (monday and wednesday) |
| Result: | Reduced urinary γ-GT by 70-78%. |
Last Update：2024-04-09 21:11:58
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Tel: 18301782025
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Mobile: 18021002903
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Multiple SpecificationsSpot supply
Product Name: Acivicin Visit Supplier Webpage Request for quotationCAS: 42228-92-2
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: Acivicin Visit Supplier Webpage Request for quotationCAS: 42228-92-2
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: Acivicin Visit Supplier Webpage Request for quotationCAS: 42228-92-2
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Product Name: Acivicin Visit Supplier Webpage Request for quotation
CAS: 42228-92-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
CAS: 42228-92-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
View History
acivicine
4-Cumylphenyl chloroformate
680618-75-1
69782-54-3
10294-42-5
3,5-Dichlorobenzeneacetic acid
1H-Indole-2,3-dione, 1-[(4-methoxyphenyl)methyl]-
N-(4-tert-Butylbenzyl)-1,3-dimethyl-4-nitro-1H-pyrazole-5-carboxamide
5-(3-(benzyloxy)phenyl)-3H-pyrrolo[2,3-d]pyrimidin-4-amine
β-Alanine, N-cyclopropyl-N-(2,2,2-trifluoroacetyl)-
4-Cumylphenyl chloroformate
680618-75-1
69782-54-3
10294-42-5
3,5-Dichlorobenzeneacetic acid
1H-Indole-2,3-dione, 1-[(4-methoxyphenyl)methyl]-
N-(4-tert-Butylbenzyl)-1,3-dimethyl-4-nitro-1H-pyrazole-5-carboxamide
5-(3-(benzyloxy)phenyl)-3H-pyrrolo[2,3-d]pyrimidin-4-amine
β-Alanine, N-cyclopropyl-N-(2,2,2-trifluoroacetyl)-