aceticacid,(p-chlorophenoxy)-,2-dimethylaminoethylester,hydrochloride
meclofenoxate hydrochloride
CAS: 3685-84-5
Molecular Formula: C12H16ClNO3.ClH
aceticacid,(p-chlorophenoxy)-,2-dimethylaminoethylester,hydrochloride - Names and Identifiers
| Name | meclofenoxate hydrochloride |
| Synonyms | brenal acefen cerutil amipolen cellative centrofenoxin centrophenoxine Meclofenoxate HCl 235anphydrochloride meclofenoxate hydrochloride chlorowodorkicentrofenoksyna centrophenoxine hydrochloride plant*cell culture dimethylaminoethyl4-chlorophenoxyacetatehydrochloride (p-chlorophenoxy)aceticacid2-(dimethylamino)ethylesterhydrochloride aceticacid,(p-chlorophenoxy)-,2-dimethylaminoethylester,hydrochloride aceticacid,(4-chlorophenoxy)-,2-(dimethylamino)ethylester,hydrochloride |
| CAS | 3685-84-5 |
| EINECS | 222-975-3 |
| InChI | InChI=1/C12H16ClNO3.ClH/c1-14(2)7-8-16-12(15)9-17-11-5-3-10(13)4-6-11;/h3-6H,7-9H2,1-2H3;1H |
aceticacid,(p-chlorophenoxy)-,2-dimethylaminoethylester,hydrochloride - Physico-chemical Properties
| Molecular Formula | C12H16ClNO3.ClH |
| Molar Mass | 294.17 |
| Density | 1.3255 (rough estimate) |
| Melting Point | 133-135°C |
| Boling Point | 345.9°C at 760 mmHg |
| Flash Point | 163°C |
| Solubility | DMSO (Sparingly), Methanol (Slightly) |
| Vapor Presure | 5.95E-05mmHg at 25°C |
| Appearance | Solid |
| Color | White to Off-White |
| Merck | 14,5780 |
| Storage Condition | −20°C |
| Refractive Index | 1.6140 (estimate) |
| Use | Used as a central nervous stimulant |
aceticacid,(p-chlorophenoxy)-,2-dimethylaminoethylester,hydrochloride - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| RTECS | AG0440000 |
| Toxicity | LD50 in mice (mg/kg): 330 i.v.; 1750 orally; 845 i.p. (Rumpf, Thuillier) |
aceticacid,(p-chlorophenoxy)-,2-dimethylaminoethylester,hydrochloride - Standard
Authoritative Data Verified Data
This product is 2-(dimethylamino) ethyl-p-chlorophenoxyacetic acid ester hydrochloride. Calculated as dry product, containing C12H16CINO3 • HCl shall not be less than 98.5%.
Last Update：2024-01-02 23:10:35
aceticacid,(p-chlorophenoxy)-,2-dimethylaminoethylester,hydrochloride - Trait
Authoritative Data Verified Data
- This product is white crystalline powder; Slightly specific odor.
- This product is very soluble in water, dissolved in dichloromethane, and almost insoluble in acetic acid.
melting point
The melting point of this product (General 0612) is 137~142°C.
Last Update：2022-01-01 14:21:43
aceticacid,(p-chlorophenoxy)-,2-dimethylaminoethylester,hydrochloride - Differential diagnosis
Authoritative Data Verified Data
- take about 10mg of this product, add 1 ml of acetic anhydride and acetic acid test solution, heat with small fire, and gradually develop deep purple-red.
- take about 10mg of this product, add 1 ml of water to dissolve, add several drops of bromine test solution, which will produce light yellow precipitate or turbidity.
- The infrared absorption spectrum of this product should be consistent with that of the control (Spectrum set 331).
- This product is chloride identification reaction (General 0301).
Last Update：2022-01-01 14:21:43
aceticacid,(p-chlorophenoxy)-,2-dimethylaminoethylester,hydrochloride - Exam
Authoritative Data Verified Data
acidity
take 0.20g of this product and add 20ml of water to dissolve. The pH value should be 3.5~4.5 (General rule 0631).
clarity of the solution
take l.Og of this product, add 10ml of water to dissolve, the solution should be clarified. (For injection)
sulfate
take l.Og of this product and check it according to law (General rule 0802). Compared with the control solution made of 4.8ml of standard potassium sulfate solution, it should not be more concentrated (0.O 48%).
organic acids
take this product 2.Og, add ether 50ml, shake for 10 minutes. Filter with G3 vertical melting funnel, the residue is washed with diethyl ether 2 times, each time 5ml, wash and filtrate, add neutral ethanol 50ml and phenolphthalein indicator solution 5 drops, with sodium hydroxide titration solution (0.lmol/L) titration, consumption of sodium hydroxide titration solution (0.lmol/L) not over 0.54.
Related substances
new system for clinical use. Take about 50mg of this product, weigh it accurately, put it in a 50ml measuring flask, add an appropriate amount of solvent [water (adjust pH to 2.5 with phosphoric acid)-acetonitrile (4060)], shake to dissolve, and diluted to the scale, shake, as a test solution; Precision take 1ml, 100ml flask, diluted with the above solvent to the scale, shake, as a control solution. Test according to high performance liquid chromatography (General 0512). Silica gel bonded with eighteen alkyl silane was used as the filler, and 0.05mol/L sodium octane sulfonate (adjusted to pH 2.5 with phosphoric acid)-acetonitrile (65:35) was used as the mobile phase, and the detection wavelength was 225nm. Take about 10mg of this product, put it in a 10ml measuring flask, add 4ml of water to dissolve, heat it in a water bath for 5 minutes, dilute it with acetonitrile to the scale, shake well, and inject l0ul into the liquid chromatograph, the degree of separation of the meclofenoxate peak from the hydrolysis product peak (relative retention time about 0.6) should be greater than 6.0. 1 Ou1 of the test solution and the control solution were respectively injected into the liquid chromatograph, and the chromatogram was recorded to 2 times of the retention time of the main component peak. If there are impurity peaks in the chromatogram of the test solution, the area of a single impurity peak shall not be greater than 0.5 times (0.5%) the area of the main peak of the control solution, and the sum of the areas of each impurity peak shall not be greater than the area of the main peak of the control solution (1.0%).
loss on drying
take this product, dry to constant weight at 105°C, weight loss should not exceed 1.0% (for oral use) or 0.5% (for injection) (General 0831).
ignition residue
not more than 0.1% (General rule 0841).
Heavy metals
take 1.0g of this product, add 23ml of water to dissolve, add 2ml of acetate buffer (pH 3.5), and check according to law (General rule 0821 first law), containing heavy metals shall not exceed 10 parts per million.
sterile
take this product, respectively, plus sterile water made from each lml containing about 25mg of the solution, according to law inspection (General 1101 ), should comply with the provisions. (For injection)
Last Update：2022-01-01 14:21:44
aceticacid,(p-chlorophenoxy)-,2-dimethylaminoethylester,hydrochloride - Content determination
Authoritative Data Verified Data
take this product about 0.2g, precision weighing, add glacial acetic acid 15ml dissolved, add acetic anhydride 45ml, according to the potential titration method (General rule 0701), with perchloric acid titration solution (0.1 mol/L) titration, and the titration results were corrected with a blank test. Each 1 ml of perchloric acid titration solution (0.1 mol/ L) corresponds to 29.42mg of C12H16C1N03. HCl.
Last Update：2022-01-01 14:21:45
aceticacid,(p-chlorophenoxy)-,2-dimethylaminoethylester,hydrochloride - Category
Authoritative Data Verified Data
cerebral metabolism improving drugs.
Last Update：2022-01-01 14:21:45
aceticacid,(p-chlorophenoxy)-,2-dimethylaminoethylester,hydrochloride - Storage
Authoritative Data Verified Data
light shielding, sealed storage.
Last Update：2022-01-01 14:21:45
aceticacid,(p-chlorophenoxy)-,2-dimethylaminoethylester,hydrochloride - Meclofenoxate Hydrochloride Capsules
Authoritative Data Verified Data
This product contains meclofenoxate hydrochloride (C12H16C1N03 • HCl) should be 93.0% ~ 107.0% of label amount.
trait
The content of this product is white or white powder.
identification
- (1) take an appropriate amount of the contents of this product, and show the same reaction according to the Identification Test (1) under the item of meclofenoxate hydrochloride.
- ( 2) take an appropriate amount of the content of this product (about 20mg equivalent to meclofenoxate hydrochloride), add 20ml of water, shake to dissolve meclofenoxate hydrochloride, filter, take the filtrate, the same reaction was shown according to the tests of identification (2) and (4) under the item of meclofenoxate hydrochloride.
- (3) in the chromatogram recorded under the content determination item, the retention time of the main peak of the test solution should be consistent with the retention time of the main peak of the reference solution.
examination
- new system of related substances in clinical use. Take the contents under the item of difference in loading, weigh properly (about 50mg of meclofenoxate hydrochloride), and put them in a 50ml measuring flask, add an appropriate amount of solvent [water (adjust pH to 2.5 with phosphoric acid)-acetonitrile (40:60)], shake to dissolve meclofenoxate hydrochloride, dilute to the scale, shake well, after filtration, the secondary filtrate was taken as a test solution. The determination was carried out according to the method for related substances of meclofenoxate hydrochloride. If there are impurity peaks in the chromatogram of the test solution, the area of a single impurity peak shall not be greater than 0.5 times (0.5%) the area of the main peak of the control solution, and the sum of the areas of each impurity peak shall not be greater than the area of the main peak of the control solution (1.0%).
- others should comply with the relevant provisions under the capsule (General 0103).
Content determination
- measured by high performance liquid chromatography (General 0512).
- chromatographic conditions and system suitability test using eighteen alkyl silane bonded silica gel as filler; 0.05mol/ L sodium octane sulfonate solution (adjusted to pH 2.5 with phosphoric acid)-acetonitrile (65:35) the detection wavelength was 225nm. Take about 10mg of meclofenoxate hydrochloride, put it in a 10ml measuring flask, add 4ml of water to dissolve, heat it in a water bath for 5 minutes, dilute it with acetonitrile to the scale, shake well, and inject 10u1 into the liquid chromatograph, the degree of separation of the meclofenoxate peak from the hydrolysate peak (relative retention time of about 0.6) should be greater than 6.0.
- determine the contents under the item of difference in loading, mix evenly, weigh an appropriate amount (equivalent to 50mg of meclofenoxate hydrochloride) accurately, and place it in a 50ml measuring flask, add an appropriate amount of solvent [water (adjust pH to 2.5 with phosphoric acid)-acetonitrile (40:60)], shake to dissolve meclofenoxate hydrochloride, dilute to the scale, shake well, filter, Take 5ml of the filtrate accurately, put it in a 50ml measuring flask, dilute it to the scale with the above solvent, shake it well, use it as a test solution, and take lOul and inject it into human liquid chromatograph, record the chromatogram; Take an appropriate amount of reference substance of meclofenoxate hydrochloride, weigh it precisely, add the above solvent to dissolve and quantitatively dilute it to make it contain about 0 in 1 ml. lmg solution, the same method for determination. According to the external standard method to calculate the peak area, that is.
category
with meclofenoxate hydrochloride.
specification
(1)0.lg (2)0.2g
storage
light shielding, sealed storage.
Last Update：2022-01-01 14:21:46
aceticacid,(p-chlorophenoxy)-,2-dimethylaminoethylester,hydrochloride - Meclofenoxate Hydrochloride for Injection
Authoritative Data Verified Data
This product is meclofenoxate hydrochloride sterile powder or crystalline powder or sterile lyophilized products. The content of meclofenoxate hydrochloride (C12H16CINO3 • HCl) shall be between 93.0% and 107.0% of the labeled amount calculated as the average loading.
trait
This product is white crystal or crystalline powder, or white or white loose lumps or powder.
identification
- the same reaction was observed according to the tests of (1), (2) and (4) for the identification of meclofenoxate hydrochloride.
- in the chromatogram recorded under the content determination item, the retention time of the main peak of the test solution should be consistent with the retention time of the main peak of the reference solution.
examination
- acidity: take this product and add water to make a solution containing about 10 mg per lml, and determine it according to law. The pH value should be 3.5~4.5 (General 0631).
- clarity of solution take this product, add water to dissolve and dilute to make a solution containing about 50mg per 1 ml, the solution should be clear; If it is turbid, compared with No. 1 turbidity standard solution (General Principles 0902 first method), should not be more concentrated.
- new system of related substances in clinical use. Take the contents under the item of difference in loading, weigh properly (about 50mg of meclofenoxate hydrochloride), and put them in a 50ml measuring flask, add an appropriate amount of solvent [water (adjust pH to 2.5 with phosphoric acid)-acetonitrile (40:60)], shake to dissolve meclofenoxate hydrochloride, dilute to the scale, shake well, as a test solution. The determination was carried out according to the method for related substances of meclofenoxate hydrochloride. If there are impurity peaks in the chromatogram of the test solution, the area of a single impurity peak shall not be greater than 0.5 times (0.5%) the area of the main peak of the control solution, and the sum of the areas of each impurity peak shall not be greater than the area of the main peak of the control solution (1.0%).
- weight loss on drying this product shall be dried at 105°C to constant weight, and the weight loss shall not exceed 1.0% (General rule 0831).
- the bacterial endotoxin of this product shall be taken and checked according to law (General rule 1143). The amount of endotoxin contained in each 1 mg of meclofenoxate hydrochloride shall be less than 1.0EU.
- sterile take this product, dissolve and dilute with 0.9% sterile sodium chloride solution to prepare a solution containing about 15mg per 1 ml, and treat it by membrane filtration, wash with 0.1% sterile peptone aqueous solution (not less than 300ml per membrane), use Staphylococcus aureus as positive control bacteria, and check according to law (General rule 1101).
- others should comply with the relevant provisions under injection (General 0102).
Content determination
- measured by high performance liquid chromatography (General 0512).
- chromatographic conditions and system suitability test using eighteen alkyl silane bonded silica gel as filler; 0.05mol/L sodium octane sulfonate solution (adjusted to pH 2.5 with phosphoric acid)-acetonitrile (65:35) the detection wavelength was 225nm. Take about 10 mg of meclofenoxate hydrochloride, put it in a 10ml measuring flask, add 4ml of water to dissolve it, heat it in a water bath for 5 minutes, dilute it with acetonitrile to the scale, shake well, and inject 10u1 into human liquid chromatograph, the degree of separation of the meclofenoxate peak from the hydrolysate peak (relative retention time of about 0.6) should be greater than 6.0.
- determine the contents under the item of difference in loading, mix evenly, weigh an appropriate amount (equivalent to 50mg of meclofenoxate hydrochloride) accurately, and place it in a 50m l measuring flask, add an appropriate amount of solvent [water (adjusted to pH 2.5 with phosphoric acid)-acetonitrile (40:60)], shake to dissolve meclofenoxate hydrochloride, dilute to the scale, and shake well, filter, Take 5ml of the filtrate accurately, put it in a 50ml measuring flask, dilute it to the scale with the above solvent, shake it, use it as a test solution, take lOul accurately, and inject it into the liquid chromatograph, record the chromatogram; Take the reference substance of meclofenoxate hydrochloride, precisely weigh it, add the above solvent to dissolve and quantitatively dilute it to make it contain about O per 1 ml. lmg solution, the same method for determination. According to the external standard method to calculate the peak area, that is.
category
with meclofenoxate hydrochloride.
specification
(1)0.06g (2)0.lg (3)0.2g (4)0.25g
storage
light shielding, closed storage.
Last Update：2022-01-01 14:21:47
aceticacid,(p-chlorophenoxy)-,2-dimethylaminoethylester,hydrochloride - Reference Information
| use | meclofenoxate hydrochloride is a brain stimulant. In addition, it is also used as a plant growth regulator. used as central nervous system stimulant mainly acts on the cerebral cortex, it can promote the redox of brain cells, regulate the metabolism of nerve cells, increase the utilization of sugars and excite the inhibited central nervous system. Traumatic coma, enuresis in children, disturbance of consciousness, senile psychosis, various dementias, alcoholism, etc. |
| biological activity | Meclofenoxate (Centrophenoxine) HCl is an anti-aging drug used to treat senile dementia and Alzheimer's disease, and can also inhibit the activity of cholinephosphotransferase. |
| category | toxic substances |
| toxicity classification | poisoning |
| acute toxicity | oral-rat LD50:865 mg/kg; Oral-mouse LD50: 1750 mg/kg |
| flammability hazard characteristics | flammability; heat decomposition releases extremely toxic nitrogen oxides, chloride and hydrogen chloride fumes |
| storage and transportation characteristics | warehouse ventilation and low temperature drying |
| fire extinguishing agent | dry powder, foam, sand |
Last Update：2024-04-09 02:00:05
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Multiple SpecificationsSpot supply
Product Name: Centrophenoxine hydrochloride Visit Supplier Webpage Request for quotationCAS: 3685-84-5
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: Meclofenoxate hydrochloride Visit Supplier Webpage Request for quotationCAS: 3685-84-5
Tel: +86 0571-86722205
Email: sales@chinaskyrun.com
Mobile: +8618958170122
QQ: 2531159185
Wechat: chinaskyrun
Spot supply
Product Name: Meclofenoxate hydrochloride Visit Supplier Webpage Request for quotationCAS: 3685-84-5
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
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View History
aceticacid,(p-chlorophenoxy)-,2-dimethylaminoethylester,hydrochloride
2-(1H-Indol-3-yl)ethyl quinoline-1(2H)-carboxylate
H-Phe-Asp-OH
4-(1-benzofuran-2-ylcarbonyl)-5-[4-(dimethylamino)phenyl]-1-{5-[(2-fluorobenzyl)sulfanyl]-1,3,4-thiadiazol-2-yl}-3-hydroxy-1,5-dihydro-2H-pyrrol-2-one
5-[2-[4-(1,2-Benzisothiazol-3-yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-2H-indol-2-one hydrochloride
Bicyclo[1.1.1]pentane-1,3-diamine dihydrochloride
165824-75-9
DL-Serine Hydrazide Hydrochloride
1-(TERT-BUTOXYCARBONYL)-1,2,3,4-TETRAHYDRO-6-QUINOLINYLBORONIC ACID
3-(4-methoxyphenyl)-2-sulfanyl-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4(3H)-one
2-(1H-Indol-3-yl)ethyl quinoline-1(2H)-carboxylate
H-Phe-Asp-OH
4-(1-benzofuran-2-ylcarbonyl)-5-[4-(dimethylamino)phenyl]-1-{5-[(2-fluorobenzyl)sulfanyl]-1,3,4-thiadiazol-2-yl}-3-hydroxy-1,5-dihydro-2H-pyrrol-2-one
5-[2-[4-(1,2-Benzisothiazol-3-yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-2H-indol-2-one hydrochloride
Bicyclo[1.1.1]pentane-1,3-diamine dihydrochloride
165824-75-9
DL-Serine Hydrazide Hydrochloride
1-(TERT-BUTOXYCARBONYL)-1,2,3,4-TETRAHYDRO-6-QUINOLINYLBORONIC ACID
3-(4-methoxyphenyl)-2-sulfanyl-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4(3H)-one