Z-THREONINE
N-Carbobenzyloxy-L-threonine
CAS: 19728-63-3
Molecular Formula: C12H15NO5
Z-THREONINE - Names and Identifiers
| Name | N-Carbobenzyloxy-L-threonine |
| Synonyms | Z-Thr Z-L-Thr Z-Thr-OH Z-THR-OH Z-L-THR-OH Z-THREONINE Z-L-THREONINE Cbz-L-threonine N-Cbz-L-Threonine N-Carbobenzyloxy-L-threonine N-benzyloxycarbonyl-l-threonine N-[(benzyloxy)carbonyl]threonine N-ALPHA-BENZYLOXYCARBONYL-L-THREONINE benzyl [(1S,2R)-1-carbamoyl-2-hydroxypropyl]carbamate (2S,3R)-2-{[(benzyloxy)carbonyl]amino}-3-hydroxybutanoate |
| CAS | 19728-63-3 |
| EINECS | 243-258-1 |
| InChI | InChI=1/C12H16N2O4/c1-8(15)10(11(13)16)14-12(17)18-7-9-5-3-2-4-6-9/h2-6,8,10,15H,7H2,1H3,(H2,13,16)(H,14,17)/t8-,10+/m1/s1 |
Z-THREONINE - Physico-chemical Properties
| Molecular Formula | C12H15NO5 |
| Molar Mass | 253.25 |
| Density | 1.2499 (rough estimate) |
| Melting Point | 101-103°C(lit.) |
| Boling Point | 396.45°C (rough estimate) |
| Specific Rotation(α) | -4.7 º (c=4, acetic acid) |
| Flash Point | 261.3°C |
| Solubility | almost transparency in Methanol |
| Vapor Presure | 3.7E-11mmHg at 25°C |
| Appearance | White to light yellow crystal powder |
| Color | White to Almost white |
| BRN | 2335409 |
| pKa | 3.58±0.10(Predicted) |
| Storage Condition | Sealed in dry,Store in freezer, under -20°C |
| Refractive Index | -4.9 ° (C=2, AcOH) |
| MDL | MFCD00065948 |
| Use | Used for biochemical reagents, peptide synthesis. |
Z-THREONINE - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36 - Wear suitable protective clothing. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| WGK Germany | 3 |
| HS Code | 29242990 |
Z-THREONINE - Reference Information
| preparation | add 50mL of L-Thr(30mmol) and cooled saturated Na2CO3 solution into a 250mL reaction bottle, and stir and dissolve in an ice bath. Drop 20mL of Z-OSu(39.4mmol) acetone solution into the reaction bottle; Stir the reaction at 25 ℃, TLC-UV fluorescence and ninhydrin color method monitor the reaction process. After the reaction, add H2O 20mL, extract with Et2O(30mL × 2) at pH>9, collect the aqueous phase, adjust the pH to 3~4 with 1.5NHCl, extract with EtOAc(30mL × 3), combine the organic phase, wash with saturated NaCl solution (25mL × 2), dry with anhydrous Na2SO4, check the purity by TLC-ultraviolet fluorescence and ninhydrin color development method, and evaporate under reduced pressure, vacuum drying to obtain a yellowish oily liquid N-benzyloxycarbonyl-L-threonine, which is stored at low temperature. |
| Use | CBZ-L-threonine is the N-Cbz protected form of L-threonine (T405500). L-threonine is an essential amino acid and is commonly used as a feed and food additive. The mutant strain of Escherichia coli produced large quantities of L-threonine for research and food nutrition purposes. L-threonine is naturally found in fish and poultry and is incorporated into some of the body's important proteins, such as hemoglobin and insulin. Used for biochemical reagents and peptide synthesis. |
Last Update：2024-04-10 22:29:15
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View History
Z-THREONINE
N-芴甲氧羰基-N'-叔丁氧羰基-N'-异丙基-L-赖氨酸
2-Chloro-3-fluoropyridine-4-carboxaldehyde hydrate, 2-Chloro-3-fluoro-4-formylpyridine hydrate
Aviptadil acetate
3-脲基丙基三甲氧基硅烷
3-碘-5-甲氧基-苯甲酸乙酯
Moexipril Intermediate
{4-[(3,5-dimethyl-1H-pyrazol-1-yl)methyl]-3-fluorophenyl}methanamine
3-氨基羰基苯硼酸
1-甲基吡唑-3-羧酸乙酯
N-芴甲氧羰基-N'-叔丁氧羰基-N'-异丙基-L-赖氨酸
2-Chloro-3-fluoropyridine-4-carboxaldehyde hydrate, 2-Chloro-3-fluoro-4-formylpyridine hydrate
Aviptadil acetate
3-脲基丙基三甲氧基硅烷
3-碘-5-甲氧基-苯甲酸乙酯
Moexipril Intermediate
{4-[(3,5-dimethyl-1H-pyrazol-1-yl)methyl]-3-fluorophenyl}methanamine
3-氨基羰基苯硼酸
1-甲基吡唑-3-羧酸乙酯