Molecular Formula | C21H23FN2O4 |
Molar Mass | 386.42 |
Density | 1?+-.0.06 g/cm3(Predicted) |
Boling Point | 630.5±55.0 °C(Predicted) |
Appearance | White solid |
pKa | 11.07±0.46(Predicted) |
Storage Condition | Inert atmosphere,2-8°C |
In vitro study | Z-FA-FMK inhibits the degradation of fibrillar collagen by fibroblasts and osteoclasts. Z-FA-FMK inhibits LPS-induced cytokine production by inhibiting the expression of NF-kappaB-dependent genes in macrophages. In vitro experiments, Z-FA-FMK effectively blocked mitogen and IL-2 induced T cell proliferation. |
In vivo study | In a mouse model of intranasal Pneumonia cocci infection, Z-FA-FMK significantly increased the growth of Pneumonia cocci in the lungs and blood. In severe comprehensive immunodeficient mice, Z-FA-FMK blocked Ras oncogenic tumors and respiratory virus infection of host heart tissue. |
HS Code | 29145090 |
biological activity | Z-FA-FMK ((1S)-Z-FA-FMK) is an irreversible cysteine protease inhibitor and can also inhibit Caspases. |
target | TargetValue cysteine protease |
Target | Value |
in vitro study | Z-FA-FMK inhibit the degradation of fibrous collagen through fibroblasts and osteoclasts. Z-FA-FMK inhibits LPS-induced cytokine production by inhibiting the expression of NF-kappaB-dependent genes in macrophages. In vitro experiments, Z-FA-FMK effectively blocked mitogen and IL-2-induced T cell proliferation. |
in vivo study | in a mouse model of intranasal pneumococcal infection, Z-FA-FMK significantly increased the growth of pneumococcus in the lung and blood. In severe comprehensive immunodeficiency mice, Z-FA-FMK blocked Ras carcinogenic tumors and respiratory virus infection in host heart tissues. |