Z-His(imZ)-OH - Names and Identifiers
Z-His(imZ)-OH - Physico-chemical Properties
Z-His(imZ)-OH - Introduction
L-Histidine, N,1-bis[(phenylmethoxy)carbonyl]-also known as L-histidine bis-Z-benzylcarbamoylamide (L-Histidine, N,1-bis[(phenylmethoxy)carbonyl]-), is an organic compound. The following is a description of the properties, uses, preparation and safety information of the compound:
Nature:
-Appearance: White crystalline solid
-Molecular formula: C24H22N4O6
-Molecular weight: 462.47g/mol
-Melting point: 140-145°C
-Solubility: Slightly soluble in ethanol, dimethyl sulfoxide and chloroform, almost insoluble in water
Use:
L-Histidine, N,1-bis[(phenylmethoxy)carbonyl]-Commonly used in the field of organic synthesis as an amine protecting group. It can be used to protect the amine group of histidine in order to carry out selective chemical modification when necessary, and then restore its original properties.
Preparation Method:
The preparation of L-Histidine, N,1-bis[(phenylmethoxy)carbonyl]-is usually carried out by the following steps:
1. Mix L-histidine with dimethylformamide (DMF).
2. p-Toluenesulfonyl chloride (TsCl) and diethylamine (DIPEA) were added and the reaction mixture was stirred.
3. Stir the reaction mixture at room temperature for several hours or heat the reaction for several hours until the reaction is complete.
4. Hydrochloric acid was added to acidify the impurities in the reaction mixture.
5. The solid product was obtained by filtration, then washed and dried.
Safety Information:
L-Histidine, N,1-bis[(phenylmethoxy)carbonyl]-has high security, but the following matters still need to be paid attention:
-Avoid inhaling powder or solution during operation to avoid respiratory tract irritation.
-In case of contact with skin or eyes, rinse immediately with plenty of water.
-It is recommended to operate in a well-ventilated place to avoid inhalation of dust.
-Safe practices for the storage and handling of chemicals should be strictly followed.
This is only a brief introduction to L-Histidine, N,1-bis[(phenylmethoxy)carbonyl]-. If you need more detailed information, please refer to relevant literature or consult a professional chemist.
Last Update:2024-04-10 22:29:15