Z-Asp(OtBu)-OH.H2O
Z-Asp(OtBu)-OH.H2O
CAS: 5545-52-8
Molecular Formula: C16H21NO6
Z-Asp(OtBu)-OH.H2O - Names and Identifiers
| Name | Z-Asp(OtBu)-OH.H2O |
| Synonyms | ASP(OtBu)-OH Cbz-Asp(OtBu)-OH Z-Asp(OtBu)-OH.H2O Z-Asp(OtBu)-OH·H2O N-CBZ-L-ASPARTIC ACID-B-T-BUTYL ESTER CBZ-L-ASPARTIC ACID 4-TERT-BUTYL ESTER Cbz-L-aspartic acid 4-tert-butyl ester N-CBZ-L-ASPARTIC ACID 4-TERT-BUTYL ESTER N-Cbz-L-Aspartic acid 4-tert-butyl ester Z-L-aspartic acid β-tert·butyl ester monohydrate N-BENZYLOXYCARBONYL-L-ASPARTIC ACID 4-TERT-BUTYL ESTER N-Benzyloxycarbonyl-L-aspartic acid 4-tert-butyl ester 4-tert-butyl hydrogen N-[(phenylmethoxy)carbonyl]-L-aspartate 4-tert-Butyl hydrogen N-((phenylmethoxy)carbonyl)-L-aspartate (2S)-2-{[(benzyloxy)carbonyl]amino}-4-tert-butoxy-4-oxobutanoic acid (non-preferred name) |
| CAS | 5545-52-8 |
| EINECS | 226-912-0 |
| InChI | InChI=1/C16H21NO6/c1-16(2,3)23-13(18)9-12(14(19)20)17-15(21)22-10-11-7-5-4-6-8-11/h4-8,12H,9-10H2,1-3H3,(H,17,21)(H,19,20)/t12-/m0/s1 |
Z-Asp(OtBu)-OH.H2O - Physico-chemical Properties
| Molecular Formula | C16H21NO6 |
| Molar Mass | 323.34 |
| Density | 1.219±0.06 g/cm3(Predicted) |
| Boling Point | 513.1±50.0 °C(Predicted) |
| Flash Point | 264.1°C |
| Solubility | Soluble in DMSO, and methanol. |
| Vapor Presure | 2.36E-11mmHg at 25°C |
| BRN | 2569846 |
| pKa | 3.67±0.23(Predicted) |
| Storage Condition | Sealed in dry,2-8°C |
| Refractive Index | 1.526 |
| MDL | MFCD00042857 |
Z-Asp(OtBu)-OH.H2O - Risk and Safety
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| HS Code | 29224999 |
Z-Asp(OtBu)-OH.H2O - Introduction
Z-Asp(OtBu)-OH. H2O (Z-Asp(OtBu)-OH.H2O) is an organic compound. The following is a description of its nature, use, preparation and safety information:
Nature:
-Appearance: Colorless solid
-Molecular formula: C16H25NO6 (including crystalline water molecules)
-Molecular weight: 343.37g/mol
-melting point: 70-75 ℃
-Solubility: Soluble in many organic solvents such as dimethyl sulfoxide.
Use:
Z-Asp(OtBu)-OH. H2O is an esterified derivative of aspartic acid. It is mainly used in the field of organic synthesis, as an amino acid protecting group (especially aspartic acid) or a starting material in the synthesis of polypeptides. In addition, it can also be used as a reagent in research and laboratory analysis.
Preparation Method:
Z-Asp(OtBu)-OH. The preparation of H2O is usually carried out by the following steps:
1. reacting aspartic acid with tert-butyl formate chloride to generate N-benzyloxycarbonyl-L-aspartic acid tert-butyl ester.
2. Under acidic conditions, the resulting tert-butyl ester is hydrolyzed to Z-Asp(OtBu)-OH.
3. The product was purified and crystallized.
Safety Information:
- Z-Asp(OtBu)-OH. H2O is generally considered safe under normal usage conditions.
-As an organic compound, appropriate laboratory safety measures should be taken, such as wearing protective gloves and goggles.
-During storage and handling, avoid contact with oxidants and strong acids to avoid dangerous reactions.
-When handling this compound, appropriate waste disposal methods should be followed to avoid pollution to the environment.
Nature:
-Appearance: Colorless solid
-Molecular formula: C16H25NO6 (including crystalline water molecules)
-Molecular weight: 343.37g/mol
-melting point: 70-75 ℃
-Solubility: Soluble in many organic solvents such as dimethyl sulfoxide.
Use:
Z-Asp(OtBu)-OH. H2O is an esterified derivative of aspartic acid. It is mainly used in the field of organic synthesis, as an amino acid protecting group (especially aspartic acid) or a starting material in the synthesis of polypeptides. In addition, it can also be used as a reagent in research and laboratory analysis.
Preparation Method:
Z-Asp(OtBu)-OH. The preparation of H2O is usually carried out by the following steps:
1. reacting aspartic acid with tert-butyl formate chloride to generate N-benzyloxycarbonyl-L-aspartic acid tert-butyl ester.
2. Under acidic conditions, the resulting tert-butyl ester is hydrolyzed to Z-Asp(OtBu)-OH.
3. The product was purified and crystallized.
Safety Information:
- Z-Asp(OtBu)-OH. H2O is generally considered safe under normal usage conditions.
-As an organic compound, appropriate laboratory safety measures should be taken, such as wearing protective gloves and goggles.
-During storage and handling, avoid contact with oxidants and strong acids to avoid dangerous reactions.
-When handling this compound, appropriate waste disposal methods should be followed to avoid pollution to the environment.
Last Update：2024-04-10 22:29:15
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