Molecular Formula | C24H20N2O3 |
Molar Mass | 384.43 |
Density | 1.273±0.06 g/cm3(Predicted) |
Solubility | 10 mM in DMSO |
Appearance | powder |
Color | , faint yellow to dark orange |
pKa | 8.84±0.20(Predicted) |
Storage Condition | 2-8°C |
Hazard Symbols | N - Dangerous for the environment |
Risk Codes | 50/53 - Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. |
Safety Description | S60 - This material and its container must be disposed of as hazardous waste. S61 - Avoid release to the environment. Refer to special instructions / safety data sheets. |
UN IDs | UN 3077 9 / PGIII |
WGK Germany | 3 |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 2.601 ml | 13.006 ml | 26.013 ml |
5 mM | 0.52 ml | 2.601 ml | 5.203 ml |
10 mM | 0.26 ml | 1.301 ml | 2.601 ml |
5 mM | 0.052 ml | 0.26 ml | 0.52 ml |
biological activity | Y16 is a G protein-coupled Rho GEFs inhibitor. It prevents the binding of LARG and Rho WITH A Kd of 80 nM. |
Target | Value |
Cell Line: | NIH 3T3 cells NIH 3T3 cells |
Concentration: | 10 μΜ, 30 μΜ 10 μΜ, 30 μΜ |
Incubation Time: | 24 hours 24 hours |
Result: | Inhibited RhoA-GTP formation induced by serum dose dependently and was specific for RhoA. Inhibited serum or SDF-1α-induced phospho-MLC and phospho-FAK formation, which were downstream of RhoA. |