WS-3
N-(6-(4-(3-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)ureido)phenoxy)pyrimidin-4-yl)cyclopropanecarboxamide
CAS: 1421227-52-2
Molecular Formula: C28H30F3N7O3
WS-3 - Names and Identifiers
WS-3 - Physico-chemical Properties
| Molecular Formula | C28H30F3N7O3 |
| Molar Mass | 569.58 |
| Density | 1.423±0.06 g/cm3(Predicted) |
| Boling Point | 632.9±55.0 °C(Predicted) |
| Solubility | DMSO: 2 mg/mL mother liquor preservation: sub-package and freeze storage to avoid repeated freezing and thawing;-20 ℃,1 month;-80 ℃,6 months (after dilution, the solution temperature is low and storage may precipitate, try to use it now) Cell experiment: Dissolve with DMSO first: dilute with culture medium then, and the dilution process is recommended to be carried out in stages to avoid too fast concentration change leading to compound precipitation. If the compound is precipitated during the dilution process, it can be redissolved by ultrasound. During dilution, ensure that the final concentration of DMSO in the working fluid should be below 0.1% as far as possible, and the maximum should not exceed 0.5%, and set up a DMSO control group with corresponding concentration. Animal experiment: Dissolve with DMSO first: dilute with water or normal saline, etc. The dilution process is recommended to be carried out in sections to avoid excessive concentration changes leading to compound pre |
| Appearance | powder |
| Color | white to beige |
| pKa | 11.82±0.20(Predicted) |
| Storage Condition | Sealed in dry,2-8°C |
| Use | WS3 is a non-specific proliferative molecule that modulates the activity of Erb3 binding protein-1 and the IκB kinase pathway. |
| Target | ErbB3-Binding Protein-1 (EBP1) ；IκB kinase |
| In vitro study | WS3 induces pancreatic R7T1 β cell proliferation in dose response, with an EC 50 value of 0.28 μM.WS3 (1.0 nM-1.0 µM) reversibly proliferate primary retinal pigment epithelial (RPE) cells isolated from fetal and adult human donors. Following withdrawal of WS3, RPE cells differentiate into a functional monolayer, as exhibited by their expression of mature RPE genes and phagocytosis of photoreceptor outer segments. |
WS-3 - Risk and Safety
| WGK Germany | 3 |
WS-3 - Reference
| Reference Show more | 1. Shen W, et al. Small-molecule inducer of β cell proliferation identified by high-throughput screening. J Am Chem Soc. 2013 Feb 6;135(5):1669-72.2. Jonathan G Swoboda, et al. Small molecule mediated proliferation of primary retinal pigment epithelial cells. ACS Chem Biol. 2013 Jul 19;8(7):1407-11. |
WS-3 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.756 ml | 8.778 ml | 17.557 ml |
| 5 mM | 0.351 ml | 1.756 ml | 3.511 ml |
| 10 mM | 0.176 ml | 0.878 ml | 1.756 ml |
| 5 mM | 0.035 ml | 0.176 ml | 0.351 ml |
Last Update：2024-01-02 23:10:35
WS-3 - Cell Experiment
R7T1 cells are growth-arrested by removal of doxycycline for 2 days and plated into 384-well plates at a density of 3,000 cells/well in growth medium. Β cell proliferation is assessed using CellTiter Glo after 4 days. Fold increase in cell number is calculated by normalizing compound-treated wells to the median of DMSO-treated wells. (Only for Reference) Cell lines: R7T1 cells
Last Update：2023-08-16 21:32:38
WS-3 - Introduction
N-(6-(4-(3-(4-(4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)ureido)phenoxy)pyrimidin-4-yl) cyclopropenecarboxamide, the full name is mixed isopropyl propylene alcohol compound -3, which is a chemical substance used for flavoring. The following is a pyrimidin-4-yl about N-(6-(4-(3-(4-(4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)ureido) phenyl) introduction to the properties, uses, formulation and safety information of cyclopropanecarboxamide:
Nature:
- N-(6-(4-(3-(4-(4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)ureido)phenoxy)pyrimidin-4-yl) the chemical name of cyclopropecarboxamide is 12-ethoxy -4,7, 9-trimethyl-1, 10-dioxopentyl-12h-cyclooct-1-one.
-The appearance is a white crystalline powder with a cool taste.
-Solid at room temperature, soluble in alcohol and ether.
Preparation Method:
- N-(6-(4-(3-(4-(4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)ureido)phenoxy)pyrimidin-4-yl) the preparation of cyclopropecarboxamide is usually obtained by synthetic chemical methods.
-It can be obtained from the reaction of isobutyl acrylate and isopropanol.
Security information:
-WS3 is safe for human health at the recommended dosage.
-However, as a chemical substance, corresponding safety operations and dosage restrictions should still be followed when using it.
-High concentrations of WS3 may cause irritation to the skin and eyes, and should be rinsed promptly upon contact. Swallowing should be avoided.
Last Update：2024-05-07 12:11:51
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Email: Int06@meryer.com
Mobile: +86-18821248368
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Product Name: WS3 Visit Supplier Webpage Request for quotationCAS: 1421227-52-2
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: WS3 Visit Supplier Webpage Request for quotationCAS: 1421227-52-2
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
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View History
WS-3
5-碘-2-甲氧基-4-甲基-苯甲酸
([1-(4-CHLOROPHENYL)-2,5-DIOXOPYRROLIDIN-3-YL]THIO)ACETIC ACID
1H-Pyrazolo[4,3-b]pyridine, 1-methyl-
UTILIS
2-([1,1'-联苯] -4-基)-2,2-二氟乙酸
1,2,3,6-四氢-4-吡啶甲酸盐酸盐
N-乙酰丙酮吗啉
C.I.Vat Black 28
1-(2,2-二苯基四氢呋喃-3-基)-N,N-二甲基甲胺盐酸盐
5-碘-2-甲氧基-4-甲基-苯甲酸
([1-(4-CHLOROPHENYL)-2,5-DIOXOPYRROLIDIN-3-YL]THIO)ACETIC ACID
1H-Pyrazolo[4,3-b]pyridine, 1-methyl-
UTILIS
2-([1,1'-联苯] -4-基)-2,2-二氟乙酸
1,2,3,6-四氢-4-吡啶甲酸盐酸盐
N-乙酰丙酮吗啉
C.I.Vat Black 28
1-(2,2-二苯基四氢呋喃-3-基)-N,N-二甲基甲胺盐酸盐