VINDESINE
vindesine
CAS: 53643-48-4
Molecular Formula: C43H55N5O7
VINDESINE - Names and Identifiers
| Name | vindesine |
| Synonyms | VDS Fildesin Eldisine VINDESINE vindesine DESACETYLVINBLASTINEAMIDE Desacetylvinblastineamide Vincaleukoblastine, 3-(aminocarbonyl)-O4-deacetyl-3-de(methoxycarbonyl)- 3-(aminocarbonyl)-o(sup4)-deacetyl-3-de(methoxycarbonyl)vincaleukoblastine 3-(aminocarbonyl)-o(sup4)-deacetyl-3-de(methoxycarbonyl)-vincaleukoblastin methyl (5S,7S,9S)-9-[(2beta,3beta,4beta,5alpha,12beta,19alpha)-3-carbamoyl-3,4-dihydroxy-16-methoxy-1-methyl-6,7-didehydroaspidospermidin-15-yl]-5-ethyl-5-hydroxy-1,4,5,6,7,8,9,14b-octahydro-2H-3,7-methanoazacycloundecino[5,4-b]indole-9-carboxylate |
| CAS | 53643-48-4 |
| EINECS | 258-682-2 |
| InChI | InChI=1/C43H55N5O7/c1-6-39(52)21-25-22-42(38(51)55-5,33-27(13-17-47(23-25)24-39)26-11-8-9-12-30(26)45-33)29-19-28-31(20-32(29)54-4)46(3)35-41(28)15-18-48-16-10-14-40(7-2,34(41)48)36(49)43(35,53)37(44)50/h8-12,14,19-20,25,27,34-36,49,52-53H,6-7,13,15-18,21-24H2,1-5H3,(H2,44,50)/t25-,27?,34+,35-,36-,39+,40-,41-,42+,43+/m1/s1 |
VINDESINE - Physico-chemical Properties
| Molecular Formula | C43H55N5O7 |
| Molar Mass | 753.93 |
| Density | 1.44g/cm3 |
| Melting Point | 230-232° |
| Specific Rotation(α) | D25 +39.4° (c = 1.0 in methanol) |
| Appearance | Cryst. |
| pKa | pKa (DMF 66%) 5.39, 7.36; (H2O) 6.04, 7.67(at 25℃) |
| Storage Condition | 2-8℃ |
| Refractive Index | 1.707 |
| Physical and Chemical Properties | Crystallized from ethanol-methanol, melting point 230-232 °c. [Α] D23 +39.4. (C = 1.0, methanol). UV absorption maximum (methanol):214,266,288,296nm (n533400, 17450,13950,12500). Pka' (dimethylformamide 66%)5.39,7.36;(water) 6.04,7.67. Vindesine Sulfate: C43H55N5O7? H2SO4. [59917-39-4]. An amorphous solid was obtained from ethanol-isopropanol, melting point> 250 °c. It is easy to decompose when exposed to heat. Acute toxicity LD50 mice, rats (mg/kg):6.3±0.6,2.0±0.2 I. V. Acute toxicity LD50 mice (mg/kg):8.8±2.5 intraperitoneal injection. |
| Use | Used as an anticancer drug |
VINDESINE - Risk and Safety
| UN IDs | 1544 |
| Hazard Class | 6.1(a) |
| Packing Group | II |
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