Molecular Formula | C20H17FN6 |
Molar Mass | 360.39 |
Density | 1.49±0.1 g/cm3(Predicted) |
Melting Point | 210.5-211.4°C |
Boling Point | 496.1±45.0 °C(Predicted) |
Solubility | DMSO: 26mg/mL at60°C |
Appearance | solid |
Color | white |
pKa | 2.71±0.10(Predicted) |
Storage Condition | Keep in dark place,Inert atmosphere,2-8°C |
In vitro study | In Vitro, BAY 41-2272 caused concentration-dependent relaxation of human and rabbit cavernous bodies with EC50 of 489.1 nM and 406.3 nM, respectively. |
In vivo study | In female spontaneously hypertensive rats, BAY 41-2272 (10 mg/kg, p.o.) exhibited an antiplatelet effect, greatly reduced blood pressure, and increased survival. In mice infected with C. Albicans, BAY 41-2272 (10 mg/kg, I. p.) not only increases macrophage function, but also significantly increases macrophage-dependent cell influx into the peritoneum, reducing mortality. In db/db-/- II diabetic and obese mice, BAY 41-2272 improved relaxation of the damaged corpus cavernosum (CC). |
Hazard Symbols | Xi - Irritant![]() |
Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
WGK Germany | 3 |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 2.775 ml | 13.874 ml | 27.748 ml |
5 mM | 0.555 ml | 2.775 ml | 5.55 ml |
10 mM | 0.277 ml | 1.387 ml | 2.775 ml |
5 mM | 0.055 ml | 0.277 ml | 0.555 ml |