UMI-77
UMI-77
CAS: 518303-20-3
Molecular Formula: C18H14BrNO5S2
UMI-77 - Names and Identifiers
UMI-77 - Physico-chemical Properties
| Molecular Formula | C18H14BrNO5S2 |
| Molar Mass | 468.34 |
| Density | 1.79±0.1 g/cm3(Predicted) |
| Boling Point | 661.2±65.0 °C(Predicted) |
| Solubility | DMSO: ≥ 28 mg/mL |
| pKa | 2.41±0.30(Predicted) |
| Storage Condition | -20℃ |
| In vitro study | UMI-77 effectively interferes with BL-Noxa and cell Mcl-1 interactions, as well as Mcl-1/Bax protein-protein interactions. UMI-77 inhibited the growth of pancreatic cancer cells with IC50 values of 3.4,4.4,12.5,16.1, 5.5, and μm for BxPC-3,Panc-1,MiaPaCa-2,AsPC-1, and Capan-2 cells, respectively. UMI-77 induces apoptosis of pancreatic cancer cells by activating the intrinsic apoptotic pathway and/or Bax conformational changes. |
| In vivo study | In a BxPC-3 xenograft mouse model, UMI-77 (60 mg/kg I. v.) exhibited a single dose of anti-tumor activity without damaging normal tissue at all. |
UMI-77 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.135 ml | 10.676 ml | 21.352 ml |
| 5 mM | 0.427 ml | 2.135 ml | 4.27 ml |
| 10 mM | 0.214 ml | 1.068 ml | 2.135 ml |
| 5 mM | 0.043 ml | 0.214 ml | 0.427 ml |
Last Update：2024-01-02 23:10:35
UMI-77 - Reference Information
| biological activity | UMI-77 is a selective Mcl-1 inhibitor with Ki of 490 nM, showing higher selectivity than other members of the Bcl-2 family. |
| in vitro studies | UMI-77 effectively interfere with the interaction between BL-Noxa and cell Mcl-1, as well as Mcl-1/Bax protein-protein interaction. UMI-77 inhibit the growth of pancreatic cancer cells, the IC50 for BxPC-3,Panc-1,MiaPaCa-2,AsPC-1 and Capan-2 cells is 3.4,4.4,12.5,16.1, and 5.5 μM respectively. UMI-77 induce apoptosis of pancreatic cancer cells by activating the inherent apoptosis pathway and/or Bax conformational changes. |
| in vivo study | in BxPC-3 xenograft mouse model, UMI-77 (60 mg/kg I. v.) showed single dose anti-tumor activity without damaging normal tissues at all. |
Last Update：2024-04-09 20:52:54
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Featured ProductsSpot supply
Product Name: UMI-77 Visit Supplier Webpage Request for quotationCAS: 518303-20-3
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: UMI-77 Visit Supplier Webpage Request for quotationCAS: 518303-20-3
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: UMI-77 Visit Supplier Webpage Request for quotationCAS: 518303-20-3
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Product Name: UMI-77 Visit Supplier Webpage Request for quotation
CAS: 518303-20-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
CAS: 518303-20-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
View History
UMI-77
2-(dimethyl-1,2-oxazol-4-yl)-1-(piperazin-1-yl)ethan-1-one
Desethyl Amlodipine
1-stearoyl-2-oleoyl-sn-glycero-3-phosphocholine
Methyl(2-hydroxyphenyl) sulfoxide
4292-25-5
1-N-BOC-吲哚-2-硼酸
5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazin-3-amine
495375-55-8
N-(Piperidin-1-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine
2-(dimethyl-1,2-oxazol-4-yl)-1-(piperazin-1-yl)ethan-1-one
Desethyl Amlodipine
1-stearoyl-2-oleoyl-sn-glycero-3-phosphocholine
Methyl(2-hydroxyphenyl) sulfoxide
4292-25-5
1-N-BOC-吲哚-2-硼酸
5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazin-3-amine
495375-55-8
N-(Piperidin-1-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine