Triethylenethiophosphoramide
Thiotepa
CAS: 52-24-4
Molecular Formula: C6H12N3PS
Triethylenethiophosphoramide - Names and Identifiers
| Name | Thiotepa |
| Synonyms | Thiotepa wr-45312 Thiofosyl Thio-TEPA Triethylenethiophosphoramide triaziridinylphosphinesulfide tris(ethylenimino)thiophosphate triethylenethiophosphorotriamide tris(1-aziridinyl)-phosphinesulfid tris(1-aziridinyl)phosphinesulphide Tris(1-aziridinyl)phosphine sulfide 1,1',1''-phosphorothioyltriaziridine N,N',N''-Triethylenethiophosphoramide |
| CAS | 52-24-4 |
| EINECS | 200-135-7 |
| InChI | InChI=1/C6H12N3PS/c11-10(7-1-2-7,8-3-4-8)9-5-6-9/h1-6H2 |
| InChIKey | FOCVUCIESVLUNU-UHFFFAOYSA-N |
Triethylenethiophosphoramide - Physico-chemical Properties
| Molecular Formula | C6H12N3PS |
| Molar Mass | 189.22 |
| Density | 1.50±0.1 g/cm3(Predicted) |
| Melting Point | 54-57 °C |
| Boling Point | 270.2±23.0 °C(Predicted) |
| Flash Point | 117.2°C |
| Water Solubility | 19 g/100 mL (25 ºC) |
| Solubility | Soluble in benzene, acetone and methanol. |
| Vapor Presure | 0.00695mmHg at 25°C |
| Appearance | White crystal |
| Color | white |
| pKa | 2.74±0.20(Predicted) |
| Storage Condition | 2-8°C |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| Refractive Index | 1.708 |
| MDL | MFCD00145452 |
| Physical and Chemical Properties | White scaly crystals or crystalline powders. Melting point of 51.5 ° C, 25 ° C water solubility of 19g/100ml, soluble in ethanol, soluble in benzene, ether, chloroform. Odorless or almost odorless. |
| Use | Has a good effect on breast cancer and ovarian cancer |
| In vitro study | Thio-TEPA exhibits alkylating activity in rat liver slice incubation. Thio-TEPA does not affect the viability of rat liver slices, and is not accumulated in the slices at all doses of 2, 5, 10 mM. |
| In vivo study | Thio-TEPA (20 mg/kg, i.p.) with total body irradiation (TBI) enhances donor-type blood chimerism during the first 10 weeks but is not dramatically higher than that of TBI group alone. Thio-TEPA alone improves both short- and long-term engraftment in mice. |
Triethylenethiophosphoramide - Risk and Safety
| Hazard Symbols | T+ - Very toxic |
| Risk Codes | R45 - May cause cancer R46 - May cause heritable genetic damage R28 - Very Toxic if swallowed |
| Safety Description | S53 - Avoid exposure - obtain special instructions before use. S22 - Do not breathe dust. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37 - Wear suitable protective clothing and gloves. S28 - After contact with skin, wash immediately with plenty of soap-suds. |
| UN IDs | UN 2811 6.1/PG 2 |
| WGK Germany | 3 |
| RTECS | SZ2975000 |
| HS Code | 2933999552 |
| Hazard Class | 6.1(a) |
| Packing Group | II |
| Toxicity | LD50 i.v. in rats: 15 mg/kg (Scherf) |
Supplier List
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CAS: 52-24-4
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Multiple SpecificationsSpot supply
Product Name: Thio-TEPA Visit Supplier Webpage Request for quotationCAS: 52-24-4
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Product Name: Tri(1-aziridinyl)phosphine sulfide Visit Supplier Webpage Request for quotationCAS: 52-24-4
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Product Name: Tri(1-aziridinyl)phosphine sulfide Visit Supplier Webpage Request for quotationCAS: 52-24-4
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
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Spot supply
Product Name: Tri(1-aziridinyl)phosphine sulfide Visit Supplier Webpage Request for quotationCAS: 52-24-4
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
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Product Name: Tri(1-aziridinyl)phosphine sulfide Visit Supplier Webpage Request for quotation
CAS: 52-24-4
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CAS: 52-24-4
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View History
Triethylenethiophosphoramide
酪里达唑
(R)-alpha-Amino-3-pyridinepropanoic acid methyl ester dihydrochloride
METHYL 5-(2-[4-(4-CHLOROPHENOXY)-3-(2,6-DICHLOROPHENYL)ISOXAZOLO[4,5-C]PYRIDIN-7-YL]VINYL)-3-(2,6-DICHLOROPHENYL)-4-ISOXAZOLECARBOXYLATE
Benzoic acid, 3,5-dichloro-4-methoxy-, 2-(2-phenylethylidene)hydrazide
Bexarotene, Free
A8576
(E)-3-[2-环丙基-4-(4-苯基)-3-喹啉基]-2-丙烯醛
-Ethyl (3-(4-((3-methyl-4-((6-methylpyridin-3-yl)
((R)-2-Aminopropyl)carbamic acid tert-butyl ester
酪里达唑
(R)-alpha-Amino-3-pyridinepropanoic acid methyl ester dihydrochloride
METHYL 5-(2-[4-(4-CHLOROPHENOXY)-3-(2,6-DICHLOROPHENYL)ISOXAZOLO[4,5-C]PYRIDIN-7-YL]VINYL)-3-(2,6-DICHLOROPHENYL)-4-ISOXAZOLECARBOXYLATE
Benzoic acid, 3,5-dichloro-4-methoxy-, 2-(2-phenylethylidene)hydrazide
Bexarotene, Free
A8576
(E)-3-[2-环丙基-4-(4-苯基)-3-喹啉基]-2-丙烯醛
-Ethyl (3-(4-((3-methyl-4-((6-methylpyridin-3-yl)
((R)-2-Aminopropyl)carbamic acid tert-butyl ester