Tolazolin
Tolazoline
CAS: 59-98-3
Molecular Formula: C10H12N2
Tolazolin - Names and Identifiers
Tolazolin - Physico-chemical Properties
| Molecular Formula | C10H12N2 |
| Molar Mass | 160.22 |
| Density | 1.0849 (rough estimate) |
| Melting Point | 66-69°C(lit.) |
| Boling Point | 188°C/20mmHg(lit.) |
| Solubility | alcohol: freely soluble |
| Appearance | Solid |
| Color | Crystals from pet ether |
| Merck | 14,9506 |
| pKa | pKa 10.3(H2Ot undefinedI = 0.1) (Uncertain) |
| Storage Condition | 2-8°C |
| Refractive Index | 1.6392 (estimate) |
| Use | This product is for scientific research only and shall not be used for other purposes. |
| In vitro study | Tolazoline (Imidaline) can be synthesized by the heterocyclation of the ethyl ester of iminophenzylacetic acid with ethylene diamine, which forms the desired product. The structure of Tolazoline (Imidaline) is strikingly similar to α-adrenergic agonists, which are antiedema sympathomimetics. |
Tolazolin - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S28 - After contact with skin, wash immediately with plenty of soap-suds. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| WGK Germany | 3 |
| RTECS | NJ1925000 |
| Toxicity | cyt-ham:lng 62,500 mg/L GMCRDC 27,95,81 |
Tolazolin - Reference Information
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| biological activity | Tolazoline(Imidaline) is a competitive alpha-adrenoceptor antagonist. |
| Target | α-adrenoptor. |
| category | toxic substances |
| toxicity grade | high toxicity |
| Acute toxicity | oral-mouse LD50: 350 mg/kg; Intraperitoneal-mouse LD50: 160 mg/kg |
| flammability hazard characteristics | flammable; Toxic nitrogen oxide gas emitted by heat |
| storage and transportation characteristics | The warehouse is ventilated and dried at low temperature; It is stored and transported separately from food raw materials |
| fire extinguishing agent | water, carbon dioxide, sand, foam |
Last Update：2024-04-09 21:04:16
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View History
Tolazolin
4H-1-Benzopyran-4-one, 5,7-dihydroxy-6-methoxy-2-(3,4,5-trimethoxyphenyl)-
Α-甲基-4-(2-甲基丙基)苯乙醛
1,3-Cyclohexadiene-1-carboxylic acid, 2-ethoxy-4-methyl-, ethyl ester
6-碘苯并呋喃-3(2H)-酮
1-Methyl 3-(hydroxymethylphosphinyl)propanoate
5-氨基-1H-吲哚-2-羧酸叔丁酯
Zinc formate
4-Thiazolecarboxylic acid, 2-(2-pyrazinyl)-
1-[3-[[[(1,1-DIMETHYLETHOXY)CARBONYL]AMINO]METHYL]PHENYL]-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-5-CARBOXYLIC ACID
4H-1-Benzopyran-4-one, 5,7-dihydroxy-6-methoxy-2-(3,4,5-trimethoxyphenyl)-
Α-甲基-4-(2-甲基丙基)苯乙醛
1,3-Cyclohexadiene-1-carboxylic acid, 2-ethoxy-4-methyl-, ethyl ester
6-碘苯并呋喃-3(2H)-酮
1-Methyl 3-(hydroxymethylphosphinyl)propanoate
5-氨基-1H-吲哚-2-羧酸叔丁酯
Zinc formate
4-Thiazolecarboxylic acid, 2-(2-pyrazinyl)-
1-[3-[[[(1,1-DIMETHYLETHOXY)CARBONYL]AMINO]METHYL]PHENYL]-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-5-CARBOXYLIC ACID