TPOP146
TPOP146
CAS: 2018300-62-2
Molecular Formula: C27H35N3O5
TPOP146 - Names and Identifiers
TPOP146 - Physico-chemical Properties
| Molecular Formula | C27H35N3O5 |
| Molar Mass | 481.58 |
| Density | 1.24±0.1 g/cm3(Predicted) |
| Boling Point | 641.8±55.0 °C(Predicted) |
| Solubility | DMSO |
| pKa | 10.68±0.20(Predicted) |
| Storage Condition | -20℃ |
| In vitro study | Exposure to 1 μM TPOP146 results in a significant decrease of recovery half-life that is comparable to the construct that contained the bromodomain inactivating mutation N1168F, demonstrating that TPOP146 targets the CBP bromodomain in the nucleus and is capable of competing with acetyl-lysine mediated interactions of the CBP bromodomain in cellular environments. |
TPOP146 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.076 ml | 10.382 ml | 20.765 ml |
| 5 mM | 0.415 ml | 2.076 ml | 4.153 ml |
| 10 mM | 0.208 ml | 1.038 ml | 2.076 ml |
| 5 mM | 0.042 ml | 0.208 ml | 0.415 ml |
Last Update：2024-01-02 23:10:35
TPOP146 - Reference Information
| biological activity | TPOP146 is a selective CBP/P300 benzodiazepam domain inhibitor; the Kd values for CBP and BRD4 were 134 nM and 5.02 μm, respectively. |
| Target | IC50: 134 nM (CBP); 5.02 μm (BRD4) |
Last Update：2024-04-09 20:49:11
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Product Name: TPOP146 Visit Supplier Webpage Request for quotationCAS: 2018300-62-2
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Product Name: TPOP146 Visit Supplier Webpage Request for quotationCAS: 2018300-62-2
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QQ: 2881950922
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Product Name: TPOP146 Visit Supplier Webpage Request for quotationCAS: 2018300-62-2
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
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Product Name: TPOP146 Visit Supplier Webpage Request for quotation
CAS: 2018300-62-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
CAS: 2018300-62-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
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