Molecular Formula | C8H8N2O2S2 |
Molar Mass | 228.29 |
Density | 1.4614 (rough estimate) |
Melting Point | 273-276℃ |
Boling Point | 200°C (rough estimate) |
Solubility | DMSO: 5mg/mL |
Appearance | Yellow crystalline solid. |
Color | Brilliant-yellow needles from 1-butanol |
pKa | 10.54±0.20(Predicted) |
Storage Condition | −20°C |
Stability | Stable for 3 years as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
Refractive Index | 1.5690 (estimate) |
Risk Codes | 28 - Very Toxic if swallowed |
Safety Description | 45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
UN IDs | UN 2811 6.1/PG 2 |
WGK Germany | 3 |
RTECS | JP1355000 |
HS Code | 29419090 |
Toxicity | LD50 in mice (mg/kg): 25 s.c.; 25 orally (Seneca) |
EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
Biological activity | Thiolutin (Acetopyrrothin) is a disulfide-containing antibiotic and anti-vascular compound produced by Streptomyces (Streptomyces). Thiolutin inhibits the JAB1/MPN/Mov34 (JAMM) metalloproteinase Csn5, SHAM-Domain-of-STAM (AMSH)-related molecules, and the specific deubiquitinase Brcc36. Thiolutin is an effective and selective inhibitor of endothelial cell adhesion and can rapidly induce phosphorylation of heat shock protein β-1 (Hsp27). |
category | pesticide |
toxicity classification | highly toxic |
acute toxicity | oral-mouse LD50: 25 mg/kg |
flammability hazard characteristics | flammability; heating decomposition releases toxic nitrogen oxides and sulfur oxide smoke |
storage and transportation characteristics | warehouse ventilation and low temperature drying |
fire extinguishing agent | dry powder, foam, sand, carbon dioxide, mist water |