Name | (4E)-TCO-PEG4-DBCO |
Synonyms | TCO-PEG4-DBCO (4E)-TCO-PEG4-DBCO |
CAS | 1801863-88-6 |
Molecular Formula | C38H49N3O8 |
Molar Mass | 675.82 |
Density | 1.22±0.1 g/cm3(Predicted) |
Boling Point | 891.1±65.0 °C(Predicted) |
pKa | 11.95±0.46(Predicted) |
Storage Condition | -20°C |
In vitro study | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. |