Molecular Formula | C12H12N2O4S2 |
Molar Mass | 312.36 |
Density | 1.48±0.1 g/cm3(Predicted) |
Melting Point | 84-86°C(lit.) |
Boling Point | 465.9±55.0 °C(Predicted) |
Solubility | acetone: 50mg/mL |
Appearance | powder |
Color | White to Light Yellow |
BRN | 1548137 |
pKa | 1.76±0.19(Predicted) |
Storage Condition | -20°C |
Stability | Hygroscopic, Moisture Sensitive |
In vitro study | Equal amounts of anti-CD11c and anti-CTLA-4 Abs (in borate buffered saline; pH 8.5) are activated using SPDP. |
Hazard Symbols | Xi - Irritant |
Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
WGK Germany | 3 |
FLUKA BRAND F CODES | 1-10 |
HS Code | 29333990 |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 3.201 ml | 16.007 ml | 32.014 ml |
5 mM | 0.64 ml | 3.201 ml | 6.403 ml |
10 mM | 0.32 ml | 1.601 ml | 3.201 ml |
5 mM | 0.064 ml | 0.32 ml | 0.64 ml |
biological activity | SPDP (SPDP Crosslinker) is a short-chain crosslinking agent, binding of the amine to the thiol group can be achieved by forming a cleavable (reducible) disulfide bond with the cysteine thiol group via the NHS-ester and pyridyl dithiol reactive groups. SPDP (SPDP Crosslinker) is a cleavable ADC linker, which can be used to synthesize antibody-conjugated drugs (ADC). |
uses | a generic hetero-functional crosslinker for proteins and enzymes. |