Name | Zaleplon |
Synonyms | Sonata ZALEPLON Zaleplon CL-284846 AKOS 92107 Zaleplon and intermediates N-[3-(3-cyanopyrazolo[1,5-a]py n-[3-(3-cyanopyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-n-ethylacetamide CL-284846, N-[3-(3-Cyanopyrazolo-[1,5-a]pyrimidin-7-yl)phenyl)-N-ethylacetamide |
CAS | 151319-34-5 |
EINECS | 604-794-5 |
InChI | InChI=1/C17H15N5O/c1-3-21(12(2)23)15-6-4-5-13(9-15)16-7-8-19-17-14(10-18)11-20-22(16)17/h4-9,11H,3H2,1-2H3 |
Molecular Formula | C17H15N5O |
Molar Mass | 305.33 |
Density | 1.25±0.1 g/cm3(Predicted) |
Melting Point | 186-1870C |
Flash Point | 9℃ |
Solubility | DMSO: ~20mg/mL |
Color | white |
pKa | -1.47±0.50(Predicted) |
Storage Condition | 2-8°C |
Refractive Index | 1.655 |
Physical and Chemical Properties | White or off-white crystal powder |
Use | For sedation and sleep |
Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R39/23/24/25 - R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed. R11 - Highly Flammable |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37 - Wear suitable protective clothing and gloves. S16 - Keep away from sources of ignition. S7 - Keep container tightly closed. |
UN IDs | UN1230 - class 3 - PG 2 - Methanol, solution |
WGK Germany | 1 |
HS Code | 2933595960 |
white or off-white crystalline powder. The melting point was 186-187 °c. Insoluble in water, slightly soluble in ethanol.
with amino acetophenone as raw material. M-aminoacetophenone and potassium carbonate are dissolved in dichloromethane, acetic anhydride is added dropwise and refluxed; It is cooled and reacted with dimethylformamide-dimethyl acetal. The filter cake was washed with water and dried to give N-[3- (3-methylamino-1-oxo-2-propenyl) phenyl] acetamide. Dissolve it in dimethylformamide, cool and add sodium hydride to react, then add bromoethane Dropwise, continue the reaction; Put ice water, stir, stand, filter, wash, dry, recrystallization from methanol gave 3-= methylamino -1-[ (3-N-ethyl-N-acetamido) phenyl]-2-propene -1-one. The product, 3-amino-4-cyanopyrazole and glacial acetic acid were mixed and heated, cooled, filtered, the filter cake was washed with acetic acid-water, dried and recrystallized from ethyl acetate to give zaleplon.
A new generation of hypnotics, with sedative hypnosis, muscle relaxation, anti Anxiety and anticonvulsant effect. Suitable for anti-Anxiety, sedative-hypnotic and anticonvulsant. It has the characteristics of short half-life and light effect, and can be used for anti Anxiety, sedative and hypnotic and anticonvulsant. Zaleplon is a new non-benzodiazepine hypnotic, the first pyrazolopyrimidine hypnotic.