Sixofilan
Schizophyllan
CAS: 9050-67-3
Molecular Formula: C24H42O21
Sixofilan - Names and Identifiers
Sixofilan - Physico-chemical Properties
| Molecular Formula | C24H42O21 |
| Molar Mass | 666.57768 |
| Physical and Chemical Properties | β-(1-3)D-glucan with β-(1-6) branches in the molecular structure of schizocin. The unique triple helix structure and appropriate branching degree (0.33) make it play a good role in regulating skin immunity, promoting skin cell proliferation, collagen synthesis, delaying aging, scavenging free radicals, resisting ultraviolet rays, repairing after sun exposure, and anti-inflammatory. In addition, it is natural water soluble and safe in source, which is very suitable for application in cosmetics and skin diseases. |
Sixofilan - References
| efficacy and action | schizocin is dextran cultured by Schizomycetes (Schizophyllum commune), which can activate Tc cells, NK cells and macrophages, promote the secretion of various lymphoid factors of IL-1, IL-2, IL-3 and IFN, and enhance immune function. schizocin is a high-tech bioengineering product refined by Schizophyllum (also known as white ginseng) through liquid submerged fermentation. schizocin promotes the production of interleukin IL-12, shows immune function, and can be used as anti-inflammatory agent. Schizocin is a water-soluble mushroom polysaccharide that can improve human immunity. Schizocin can form a stable three-helix rigid rod-like structure in an aqueous solution, which can be used by the body The receptors on the immune cells are recognized and combined to activate the biological expression of human immune cells, regulate and improve the immunity of the tissue system, and enhance the resistance to various unfavorable factors inside and outside. Because it can quickly penetrate into the skin on the surface of the skin and bind to be recognized by receptors on skin tissue cells and immune cells, it is now widely used in skin care cosmetics. When used in skin washing and protection cosmetics, it can quickly penetrate into the skin. The molecules are recognized by the immune cells in the skin and the receptors on the epidermal and dermal tissue cells and bind to activate the skin immune cells and other tissues. The activity of the cells improves the resistance and repair ability of the entire skin tissue. schizocin is used in the formula of hair washing and care products: hair follicles are the most important nutritional tissue of hair. With life pressure, eating habits, various radiation pollution and other factors caused by hair loss and gray hair increase. Schizocin can act on hair follicle cells and immune cells to regulate and enhance the health of hair follicle cells and entire tissue cells. The immunity of hair follicle cells and various tissue cells is enhanced, the nutrition of scalp and hair is fully supplied, the health level of hair and scalp will also be improved, the repaired hair follicle will grow back, and the dry, itchy and dandruff of scalp can also be completely improved. |
| physiological action | after degradation of schizophyllum (Schizophyllum commune), a polysaccharide named schizophyllum (Schizophyllan, SPG for short) can be obtained by fractional precipitation with acetone or ethanol, and the main chain is β-1, 3-pyranose, one of every 3 sugar groups is connected with a β-1, 6-pyranose. SPG dissolves in water and becomes a trimer with a rod-like rigid triple helix structure composed of three sugar chains of similar length. After ultrasonic treatment of natural polysaccharide in aqueous solution, the molecular weight is reduced from 5 × 10~6~7 × 10~6 to 4.5 × 10~5, and the viscosity is also reduced, which is conducive to purifying polysaccharide for clinical use. SPG has immunomodulatory effect on the host, resulting in anti-tumor and antibacterial effects. It can protect the host from infection by Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Mycobacterium tuberculosis and Candida albicans, but it is ineffective against pneumococcus and Enteritidis. In the anti-lung tumor effect of SPG, it can not only inhibit the same (Allogeneic) tumor (such as S-180, Ehrlich cancer and Lewis lung cancer metastasis), but also inhibit the same (Syngeneic) tumor (such as AMC-60 fibrosarcoma and RC-47 bladder cancer). |
Last Update：2024-04-09 20:52:54
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Mobile: 609-228-6898
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Product Name: Schizophyllan Visit Supplier Webpage Request for quotationCAS: 9050-67-3
Tel: +16314854226
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