Molecular Formula | C21H16ClF3N4O3 |
Molar Mass | 464.8249496 |
Melting Point | 202-204?C |
Storage Condition | -20°C Freezer |
biological activity | Donafenib (Sorafenib D3, Bay 43-9006 D3, CM-4307) is a deuterium-labeled Sorafenib. Sorafenib is a multi-kinase inhibitor with IC50 values of 6 nM, 15 nM, 20 nM and 22 nM for Raf-1, mVEGFR-2, mVEGFR-3 and B- RAF inhibition, respectively. |
Target | Value |
Raf-1 (Cell-free assay) | 6 nM |
mVEGFR-2 (Cell-free assay) | 15 nM |
mVEGFR-3 (Cell-free assay) | 20 nM |
B-Raf (Cell-free assay) | 22 nM |