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SNAC

Salcaprozate Sodium

CAS: 203787-91-1

Molecular Formula: C15H20NNaO4

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SNAC - Names and Identifiers

Name Salcaprozate Sodium
Synonyms SNAC
Salcaprozate Sodium
Salcaprozate sodium
Salcaprozate Sodium (SNAC)
sodium 8-(2-hydroxybenzamido)octanoate
sodium,8-[(2-hydroxybenzoyl)amino]octanoate
SODIUM 8-(2-HYDROXYBENZAMIDO)OCTANOATE (SNAC)
SNAC,sodium 8-[(2-hydroxybenzoyl)amino]octanoate
Octanoic acid, 8-[(2-hydroxybenzoyl)amino]-, monosodium salt
CAS 203787-91-1
EINECS 231-019-4

SNAC - Physico-chemical Properties

Molecular FormulaC15H20NNaO4
Molar Mass301.31
Storage ConditionRoom Temprature
Physical and Chemical PropertiesBioactive Salcaprozate sodium (SNAC) is an oral absorption promoter with potential as a delivery agent for oral forms of heparin and insulin. Salcaprozate sodium can increase the lipophilicity caused by non-covalent macromolecular complexation, thereby increasing the passive transcellular penetration of small intestinal epithelial cells.
UseIntroduction 8-(2-hydroxybenzamido) sodium octanoate, SNAC for short, is a two-carbon phosphate compound absorption enhancer, used in the treatment of gastrointestinal diseases, it is especially suitable for gastrointestinal diseases caused by malabsorption of two carbon phosphate compounds.

SNAC - Uses and synthesis methods

in vitro study

SNAC (12.5-400 μg/mL; 24 h) has no toxicity to Caco-2 cells, and the survival percentage is above 90% when SNAC is 200 μg/mL.

SNAC (50 and 200 μg/mL) improves the apparent permeability coeffcient (Papp) of RA and SA-B by 2.14-fold and 3.68-fold compared with the Papp of SAs solution.

in vivo studies

SNAC improves the oral absorption of both R1 and SAs and enhances bioavailability in rats.

SNAC (2000 mg/kg/d; oral gavage for 13 weeks) related mortality is evident only at the 2000-mg/kg/d level, 20% among males and 50% among females; no clear cause of death is evident.

SNAC (100-1000 mg/kg/d; oral gavage for 13 weeks) induces no mortality in the Wistar rat study at doses up to 1000 mg/kg/d.

Animal Model: Sprague-Dawley rats (6-7 weeks)

Dosage: 2000 mg/kg/d

Administration: Oral gavage for 13 weeks

Result: Induced 20% and 50% mortality in males and females at the dose of 2000 mg/kg/d.

Last Update:2024-04-09 21:01:54

SNAC - Nature

storage conditions Inert atmosphere,Room Temperature
Last Update:2024-04-09 01:59:49
SNAC
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Suzhou Haofan biological Co., Ltd.
Featured Products
Product Name: Salcaprozate Sodium Request for quotation
CAS: 203787-91-1
Tel: +86 0512-68417696
Email: chenmengqi@highfine.com
     wuhao@highfine.com
     merry@highfine.com
QQ: 4006286883 Click to send a QQ message
Jiangsu Pules Biotechnology Co.,Ltd.
Product Name: Salcaprozate Sodium Request for quotation
CAS: 203787-91-1
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
CHEMBSF (Shanghai) Biomedical Technology Co., Ltd
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Product Name: Salcaprozate Sodium Request for quotation
CAS: 203787-91-1
Tel: +86-18721521379
Email: 18721521379@163.com
Mobile: +86-18721521379
Wechat: 18721521379
Nantong Reform Petro-Chemical CO., LTD.
Spot supply
Product Name: Salcaprozate Sodium Request for quotation
CAS: 203787-91-1
Tel: +86-17551318830
Email: r@reformchem.com­
Mobile: +86-17551318830
QQ: 3785839865 Click to send a QQ messageSend QQ message
Wechat: chemical6666 
MedChemExpress (MCE)
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CAS: 203787-91-1
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Mobile: 609-228-6898
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SHANGHAI ACMEC BIOCHEMICAL TECHNOLOGY CO., LTD.
Spot supply
Product Name: Sodium 8-(2-hydroxybenzamido)octanoate Visit Supplier Webpage Request for quotation
CAS: 203787-91-1
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922 Click to send a QQ message
Wechat: 18621343501
WhatsApp: +86-18621343501
Shanghai Macklin Biochemical Co., Ltd
Spot supply
Product Name: Sodium 8-(2-hydroxybenzamido)octanoate Visit Supplier Webpage Request for quotation
CAS: 203787-91-1
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328 Click to send a QQ message
WhatsApp: +86-18821248368
Shanghai Yuanye Bio-Technology Co., Ltd.
Spot supply
Product Name: Sodium 8-(2-hydroxybenzamido)octanoate Visit Supplier Webpage Request for quotation
CAS: 203787-91-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
Shanghai Worldyang Chemical Co.,Ltd.
Product Name: Salcaprozate Sodium Request for quotation
CAS: 203787-91-1
Tel: +86-21-56795779
Email: charles7788@worldyachem.com
Mobile: +86-13651600618
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View History
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