Molecular Formula | C22H28O6 |
Molar Mass | 388.45 |
Density | 1.23±0.1 g/cm3(Predicted) |
Melting Point | 222° |
Boling Point | 586.3±50.0 °C(Predicted) |
Specific Rotation(α) | D20 +34.5° (c = 5.09 in CHCl3) |
Solubility | Soluble in DMSO |
Appearance | Powder |
Color | White to Off-White |
Storage Condition | -20°C Freezer, Under inert atmosphere |
MDL | MFCD00273126 |
In vitro study | Quassin (Compound 1; 5-25 ng/mL) inhibits both the basal and luteinizing hormone-stimulated testosterone secretion of rat Leydig cells in a dose-dependent fashion. |
EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
biological activity | Quassin (nigakil strain D) is a bioactive triterpene extracted from the stem bark extract of quasamara. Quassin inhibits P. falciparum with an IC50 of 0.15 μM. Quassin has reversible antifertility, antiestrogenic and antiplasmodium activity. |
Target | IC50: 0.15 μM ( P. falciparum ) |
Animal Model: | 35 females albino rats (150-170 g) |
Dosage: | 0.1 mg/kg, 1.0 mg/kg and 2.0 mg/kg |
Administration: | Oral administration; daily; for 60 days |
Result: | There was a significant decrease in the weight of the ovary and uterus in all the groups relative to the control. There was also a significant decrease in serum estrogen levels in quassin treated rats. |
Use | Quassin is a natural occurring extract from quassia trees and is used in traditional chinese medicine for it. Quassin have also been used as an additive in soft drinks. |