Name | 2-CHLORO-5-FLUOROPYRIMIDINE |
Synonyms | 2-Chloro-5-fluoropyr 2-Chlor-5-fluorpyrimidin 2-chloro-5fluoro-pyrimidine 5-Fluoro-2-chloropyrimidine 2-CHLORO-5-FLUOROPYRIMIDINE 2-Chloro-5-fluoropyriMidi... Pyrimidine,2-chloro-5-fluoro- 2-Chloro-5-fluoro-1,3-diazine Pyrimidine, 2-chloro-5-fluoro- Pyrimidine, 2-chloro-5-fluoro- (9CI) |
CAS | 62802-42-0 |
InChI | InChI=1/C6H3ClFNO2/c7-5-4(8)3(6(10)11)1-2-9-5/h1-2H,(H,10,11) |
InChIKey | AGYUQBNABXVWMS-UHFFFAOYSA-N |
Molecular Formula | C4H2ClFN2 |
Molar Mass | 132.52 |
Density | 1.439 g/mL at 20 °C (lit.) |
Boling Point | 149.0-162.0°C |
Flash Point | 150°F |
Vapor Presure | 9.41E-07mmHg at 25°C |
Appearance | Liquid |
Color | Clear colorless to yellow |
pKa | -2.54±0.22(Predicted) |
Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
Refractive Index | n20/D 1.503(lit.) |
Physical and Chemical Properties | Appearance colorless liquid boiling point 160-162 ℃ |
Use | Pharmaceutical Intermediates |
Risk Codes | R22 - Harmful if swallowed R34 - Causes burns R41 - Risk of serious damage to eyes R37/38 - Irritating to respiratory system and skin. |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
UN IDs | UN 2735 8/PG 2 |
WGK Germany | 3 |
HS Code | 29335990 |
Hazard Note | Harmful |
Hazard Class | IRRITANT |
Packing Group | Ⅲ |
Application | 2-chloro-5-fluoropyrimidine can be used as a pharmaceutical and biochemical intermediate, such as for the preparation of 2-hydroxy-5-fluoropyrimidine. 5-fluoropyrimidine derivative is a kind of broad-spectrum anti-tumor, high efficiency anti-metabolic drugs in clinic, it has inhibitory effect on a variety of tumors. |
preparation | add 2, 4-dichloro-5-fluoropyrimidine and reducing metal powder to the solvent, the mixture was stirred to warm up to the reaction temperature, and the acid was slowly added dropwise. After dropping, the reaction temperature was maintained until the reaction was completed. The solvent was removed by filtration, phase separation or direct evaporation, and distillation under reduced pressure to obtain 2-chloro-5-fluoropyrimidine. |