Name | 5-Bromo-2-methyl-3-nitropyridine |
Synonyms | T6NJ B1 CNW EE 5-broMo-2-Methyl-3-n 5-Bromo-3-nitropicoline 5-Bromo-3-nitro-α-picoline 5-Bromo-3-nitro-2-picoline 5-Bromo-2-methyl-3-nitrop... 5-Bromo-2-methyl-3-nitropyridine Pyridine,5-broMo-2-Methyl-3-nitro- pyridine, 5-bromo-2-methyl-3-nitro- |
CAS | 911434-05-4 |
EINECS | 200-258-5 |
InChI | InChI=1/C6H5BrN2O2/c1-4-6(9(10)11)2-5(7)3-8-4/h2-3H,1H3 |
Molecular Formula | C6H5BrN2O2 |
Molar Mass | 217.02 |
Density | 1.709 |
Melting Point | 38.0 to 42.0 °C |
Boling Point | 253 °C |
Flash Point | 107 °C |
Vapor Presure | 0.0305mmHg at 25°C |
pKa | -0.44±0.20(Predicted) |
Storage Condition | Inert atmosphere,Room Temperature |
Refractive Index | 1.599 |
MDL | MFCD09031419 |
Hazard Symbols | Xn - Harmful |
Risk Codes | 22 - Harmful if swallowed |
Use | 5-bromo-2-methyl-3-nitropyridine is a pyridine organic compound, which is mainly used as a pharmaceutical intermediate. As an important structural unit, pyridine compounds are widely existed in fine chemicals, medicines and other structures. 5-bromo-2-methyl-3-nitropyridine can be used for the synthesis of the PLK1 inhibitor mln0905. |
synthesis method | with 5-amino-2-methyl-3-nitropyridine as starting material, the target compound 5-bromo-2-methyl-3-nitropyridine was prepared by bromination reaction. Alternatively, the target compound 5-bromo-2-methyl-3-nitropyridine is prepared by methylation reaction using 5-bromo-2-chloro-3-nitropyridine as a starting material. The synthesis reaction formula is as follows: |