Name | PotassiumD-erythronate |
Synonyms | PotassiumD-erythronate Potassium (2R,3R)-2,3,4-Trihydroxybutanoate |
CAS | 88759-55-1 |
Molecular Formula | C4H9KO5 |
Molar Mass | 176.21 |
Storage Condition | Room Temprature |
HS Code | 29400090 |
Overview | potassium D-threonate can be obtained by one-step preparation of D-(-)-arabinose, they are useful in the preparation of biologically active compounds for use as oral Factor Xa inhibitors. |
Application | potassium D-threonate is a saccharide derivative and can be used as a pharmaceutical intermediate. |
synthesis method | synthesis method of potassium D-threonate: potassium hydroxide (1.12, 19.98 mol) was slowly added to a mixed solvent of Methanol (10 L) and water (2.4 L), and the temperature was controlled not to exceed 45 °c. After the addition, oxygen was introduced into the reaction solution, and D-(-)-arabinose (1kg, 6.66 Mol, dissolved in 2.4 L of water) was added dropwise until the reaction solution dropped to 35 °c. The aqueous solution was added dropwise over 6 hours (oxygen was maintained throughout) and the reaction temperature was maintained at 35 degrees. After the completion of the drip, oxygen was continued to be introduced for 2 hours, and air was further introduced for 60 hours. The reaction solution was concentrated under reduced pressure to 2.4 liters of oily matter, and the oily matter was slowly dropped into rapidly stirred methanol (10 liters) to precipitate a large amount of white solid. After completion of the dropping, filtration and vacuum drying gave a white solid (560g, yield 48%). |