Phelypressin
Felypressin
CAS: 56-59-7
Molecular Formula: C46H65N13O11S2
Phelypressin - Names and Identifiers
Phelypressin - Physico-chemical Properties
| Molecular Formula | C46H65N13O11S2 |
| Molar Mass | 1040.22 |
| Density | 1.288±0.06 g/cm3(Predicted) |
| Melting Point | >197oC (dec.) |
| Boling Point | 1571.3±65.0 °C(Predicted) |
| Flash Point | 904.1°C |
| Solubility | Freely soluble in water, practically insoluble in acetone and ethanol (96 per cent). It dissolves in dilute solutions of alkali hydroxides. |
| Vapor Presure | 0mmHg at 25°C |
| Appearance | neat |
| Color | White |
| pKa | 12.82±0.70(Predicted) |
| Storage Condition | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| Refractive Index | 1.574 |
| Physical and Chemical Properties | Synthetic vasopressin substances, that is, the tyrosine at position 2 of vasopressin is replaced by phenylalanine, and the arginine at position 8 is replaced by lysine. It has selective booster and hemostatic effects. It does not produce uterine contraction, lactation and antidiuretic effects within the range of booster and hemostatic doses. Coronary vasoconstriction is mild, and its vasoconstriction is about 5 times that of lysine vasopressin, while the antidiuretic effect is minimal, only 1/10-1/40 of vasopressin. The boost effect is moderate and the maintenance time is longer. It should be compatible with haloalkane anesthetic. When combined with epinephrine, it will not cause arrhythmia such as ventricular fibrillation. |
| In vitro study | Felypressin is a synthetic hormone of the posterior pituitary lobe characterized by vasoconstrictor properties that is widely used in dental procedures. The vasoconstrictor action of Felypressin seems to be mediated by V1 receptors of the blood vessel smooth muscle cells. |
| In vivo study | Felypressin can reduce toxicity during dental procedures. Felypressin increases the diastolic blood pressure of hypertensive patients with controlled blood pressure. Cardiovascular effects of Felypressin (240 ng/kg; intravenous injection) are studied in Wistar rats. Felypressin induces a pressor effect. Felypressin depends on V1 receptors to induce pressor and bradycardic effects, and that it produces a high relationship between bradycardia and mean arterial pressure variation depending on area postrema and central V1 receptors. |
Phelypressin - Risk and Safety
| WGK Germany | 3 |
Phelypressin - Nature
Open Data Verified Data
- This product is a synthetic vasopressin analog, that is, the 2-position tyrosine of vasopressin is replaced by phenylalanine, and the 8-position arginine is replaced by lysine.
- It has a selective pressor effect and a hemostatic effect. In the pressure and hemostatic dose range does not produce uterine contraction, lactation and antidiuretic effect, coronary vasoconstriction effect is slight. Its vasoconstrictive effect is about 5 times that of lysine vasopressin, and the antidiuretic effect is very small, only 1/10~1/40 of vasopressin. The pressor effect was relieved and maintained for a long time. It should be combined with haloalkane anaesthetics. Combined with epinephrine, do not cause ventricular fibrillation and other arrhythmias.
Last Update：2024-01-02 23:10:35
Phelypressin - Use
Open Data Verified Data
- clinically applicable to anesthesia and surgery Shock or blood pressure drop, also used for bleeding during surgery, often combined with local anesthetics.
- the usage and dosage of intravenous drip 5~10 units, normal saline diluted 100~200 times drip. Infiltration anesthesia can be 100 to 200 times the dilution of the drug in the surgical area.
Last Update：2022-01-01 11:11:35
Phelypressin - Safety
Open Data Verified Data
pale complexion and skin, desire to urinate, Abdominal Pain, Diarrhea, slow pulse, etc.; Excess will have Nausea, Vomit; Patients with coronary artery not to use; Pregnant women and the elderly with caution.
Last Update：2022-01-01 11:11:36
Phelypressin - Reference Information
| introduction | phenylisin is a synthetic polypeptide similar to vasopressin, which can contract peripheral blood vessels, raise blood pressure and stop bleeding. The boosting effect of this product is slow and lasting. Clinically, it can be used for shock, blood pressure drop and hemostasis. Intravenous administration of 5~10 units once. Adverse reactions include pale complexion, urgency of urination, abdominal pain and diarrhea. Vomiting can occur in an overdose. Pregnant women and the elderly should use it with caution. Coronary artery disease is disabled. |
| drug properties and application | phenylepressin acetate is a synthetic polypeptide similar to vasopressin, which can contract peripheral blood vessels, raise blood pressure and stop bleeding. The boost effect is slow and long-lasting. Can be used for shock, blood pressure drop and hemostasis. Intravenous drip: 5~10 units, diluted 100~200 times with normal saline, slowly drip and monitor blood pressure changes. |
| biological activity | Felypressin (PLV-2) is a non-catecholamine vasoconstrictor and a vasopressin 1 (vasopressin 1) agonist. Felypressin are widely used in dental surgery. |
| target | Vasopressin 1 |
| in vitro study | Felypressin is a synthetic hormone of the posterior pituitary lobe characterized by vasoconstrictor properties that is widely used in Dental procedures. The vasoconstrictor action of Felypressin sees to be mediated by V1 receptors of the blood vessel smooth muscle cells. |
| in vivo study | Felypressin can reduce toxicity during dental procedures. Felypressin increases the diastolic blood pressure of hypertensive patients with controlled blood pressure. Cardiovascular effects of Felypressin (240 ng/kg; intravenous injection) are studied in Wistar rats. Felypressin induces a pressor effect. Felypressin depends on V1 receptors to inuce pressor and bradycardic effects, and that it produces a high relationship between bradycardia and mean arterial pressure variation depending on area postrema and central V1 receptors. |
| chemical properties | synthetic vasopressin substances, I .e. tyrosine at position 2 of vasopressin is replaced by phenylalanine and arginine at position 8 is replaced by lysine. It has selective booster and hemostatic effects. It does not produce uterine contraction, lactation and antidiuretic effects within the range of booster and hemostatic doses. Coronary vasoconstriction is mild, and its vasoconstriction is about 5 times that of lysine vasopressin, while the antidiuretic effect is minimal, only 1/10-1/40 of vasopressin. The boost effect is moderate and the maintenance time is longer. It should be compatible with haloalkane anesthetic. When combined with epinephrine, it will not cause arrhythmia such as ventricular fibrillation. |
| use | clinically suitable for shock or blood pressure drop during anesthesia and surgery, and can also be used for bleeding during surgery, often combined with local anesthetics. Adverse reactions and contraindications: After medication, there may be symptoms such as pale complexion and skin, urination, abdominal pain, diarrhea, and slow pulse; excessive nausea and vomiting. Coronary artery patients do not use, pregnant women and the elderly with caution. |
Last Update：2024-04-09 20:52:54
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Product Name: Felypressin Visit Supplier Webpage Request for quotationCAS: 56-59-7
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Mobile: +86-18821248368
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Multiple SpecificationsSpot supply
Product Name: Felypressin Visit Supplier Webpage Request for quotationCAS: 56-59-7
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: Felypressin Visit Supplier Webpage Request for quotationCAS: 56-59-7
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: Felypressin Visit Supplier Webpage Request for quotationCAS: 56-59-7
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
View History
Phelypressin
N-[bis(2-chloroethyl)carbamoylmethyl]acetamide
(7-methyl-8-phenylpyrazolo[5,1-c][1,2,4]triazin-3-yl)(2-thienyl)methanone
N-[bis(2-chloroethyl)carbamoylmethyl]acetamide
(7-methyl-8-phenylpyrazolo[5,1-c][1,2,4]triazin-3-yl)(2-thienyl)methanone