Molecular Formula | C11H8FNO2S |
Molar Mass | 237.25 |
Solubility | DMSO: ≥ 37 mg/mL |
Appearance | powder |
Color | light orange to dark orange |
Storage Condition | -20°C |
In vitro study | In SY5Y cells, PD151746 effectively attenuated maitotoxin-induced SLLVY-AMC hydrolysis. In HMEC-1 cells, PD 151746 attenuated oxidized low density lipoprotein (oxLDL)-induced cytotoxicity. |
Safety Description | 24/25 - Avoid contact with skin and eyes. |
UN IDs | 3077 |
WGK Germany | 3 |
HS Code | 29339900 |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 4.215 ml | 21.075 ml | 42.15 ml |
5 mM | 0.843 ml | 4.215 ml | 8.43 ml |
10 mM | 0.421 ml | 2.107 ml | 4.215 ml |
5 mM | 0.084 ml | 0.421 ml | 0.843 ml |
Biological activity | PD 151746 is a selective, cell-permeable calpain inhibitor. The Ki for μ-Calpain is 2.6M, which is about 20 times higher than m-Calpain selectivity. |
in vitro study | in SY5Y cells, PD151746 effectively weaken the SLLVY-AMC hydrolysis induced by maitotoxin. In HMEC-1 cells, PD 151746 attenuates oxidized low density lipoprotein (oxLDL)-induced cytotoxicity. |