Name | Estazolam |
Synonyms | ProSom Julodin Nemurel Nuctalon Estazolam estazolam--dea schedule iv item estazolam 100 ug per ml in methanol 3-a)(1,4)benzodiazepine,8-chloro-6-phenyl-4h-s-triazolo( 4H-s-Triazolo(4,3-a)(1,4)benzodiazepine, 8-chloro-6-phenyl- 8-chloro-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine 2,4)triazolo(4,3-a)(1,4)-benzodiazepine,8-chloro-6-phenyl-4h-( 4H-[1,2,4]Triazolo[4,3-a][1,4]benzodiazepine, 8-chloro-6-phenyl- |
CAS | 29975-16-4 |
EINECS | 249-982-4 |
InChI | InChI=1/C16H11ClN4/c17-12-6-7-14-13(8-12)16(11-4-2-1-3-5-11)18-9-15-20-19-10-21(14)15/h1-8,10H,9H2 |
Molecular Formula | C16H11ClN4 |
Molar Mass | 294.74 |
Density | 1.2294 (rough estimate) |
Melting Point | 228-229° |
Boling Point | 448.04°C (rough estimate) |
Flash Point | 11°C |
Vapor Presure | 9.55E-10mmHg at 25°C |
pKa | pKa 2.84(H2O) (Uncertain) |
Storage Condition | 2-8°C |
Refractive Index | 1.6110 (estimate) |
Physical and Chemical Properties | White or yellowish crystals or powders. Melting point 228-229. Soluble in chloroform, slightly soluble in methanol, insoluble in acetone, ethanol, ethyl acetate and benzene. Almost insoluble in ether and water, odorless, bitter taste. |
Use | Central nervous system, can sleep, sedation, anticonvulsant, anti Anxiety |
Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R39/23/24/25 - R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed. R11 - Highly Flammable |
Safety Description | S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37 - Wear suitable protective clothing and gloves. S16 - Keep away from sources of ignition. S7 - Keep container tightly closed. |
UN IDs | 3249 |
WGK Germany | 3 |
RTECS | XZ5473500 |
HS Code | 2933910000 |
Hazard Class | 6.1(b) |
Packing Group | III |
Toxicity | LD50 orally in male mice, rats and rabbits: 740, 3200, 300 mg/kg (Yokotani) |
This product is 6-phenyl-8-chloro-4h-[l,2,4]-triazole [4,3-a][l,4] Benzodiazepine cover. Calculated as dried product, the content of C16H11C1N4 shall not be less than 98.5%.
The melting point of this product (General 0612) is 229~232°C.
take this product, precision weighing, and hydrochloric acid solution (9- 1000) dissolved and quantitatively diluted to make a solution containing about lOug per lml, the absorbance was measured at a wavelength of 0401 NM according to ultraviolet-visible spectrophotometry (General rule 349), and the absorption coefficient was 367.
take this product l. Add 50ml of water, shake for 10 minutes, filter; Take 25ml of filtrate, check according to law (General rule 0801), and standard sodium chloride solution 7. 0ml of the control solution should not be more concentrated (0.014%).
take this product, add mobile phase to dissolve and dilute to make a solution containing 0.2mg per 1 ml as a test solution; Take appropriate amount with precision, as a control solution, a solution containing about 2ug per 1 ml was prepared by dilution with mobile phase. Determined by high performance liquid chromatography (General 0512). Silica gel bonded with eighteen alkyl silane was used as the filler; Methanol-water (65:35) was used as the mobile phase; The detection wavelength was 223mn. The number of theoretical plates shall not be less than 2000 based on the calculation of estazolam peak. 20ul of control solution and 20ul of test solution were respectively injected into human liquid chromatograph, and the chromatogram was recorded to 3 times of the retention time of the main component chromatographic peak. If there are impurity peaks in the chromatogram of the test solution, the sum of each impurity peak area shall not be greater than 0.5 times (0.5%) of the main peak area of the control solution.
take this product, dry to constant weight at 105°C, weight loss shall not exceed 0.5% (General rule 0831).
not more than 0.1% (General rule 0841).
take this product about 0.lg, precision weighing, add acetic anhydride 50ml dissolved, add crystal violet indicator 2 drops, with perchloric acid titration solution (0.1 mol/L) titration to the solution yellow, and the results of the titration with blank test correction. Each 1 ml of perchloric acid titration solution (0.1 mol/L) corresponds to 14.74mg of C16H11C1N4.
Anti-Anxiety drug.
sealed storage.
This product contains estazolam (C16H11C1N4) should be 90.0% ~ 110.0% of the label amount.
This product is white tablet.
take an appropriate amount of fine powder of this product (about 10 mg equivalent to estazolam), add 10ml of ethanol, shake to dissolve estazolam, filter, evaporate the filtrate, identify the residue under the item of estazolam (1) (2) the test showed the same reaction.
Take 30 tablets of this product, precision weighing, fine grinding, precision weighing appropriate amount (about equivalent to estazolam lOmg), put in 100ml measuring flask, add hydrochloric acid solution (9-1000)60ml, fully shake to dissolve estazolam, dilute to the scale with hydrochloric acid solution (9-1000), shake well, filter, accurately take 5ml continuous filtrate, put 50ml flask, use hydrochloric acid solution (9-1000) dilute to the scale, shake, according to UV-visible spectrophotometry (General 0401), at the wavelength of 268mn absorbance, Cl6H11ClN4 absorption coefficient is calculated as 352, obtained.
Same as estazolam.
(l ) lmg (2)2mg
light shielding, sealed storage.
This product is a sterile aqueous solution made of estazolam with suitable cosolvent. The inclusion of esmlen (C16H11ClN4) shall be between 90.0% and 110.0% of the label amount.
This product is a clear colorless liquid.
Same as estazolam.
(l) lml : lmg (2)lml : 2mg
light shielding, closed storage.