NSC764414
L-002
CAS: 321695-57-2
Molecular Formula: C15H15NO5S
NSC764414 - Names and Identifiers
NSC764414 - Physico-chemical Properties
| Molecular Formula | C15H15NO5S |
| Molar Mass | 321.35 |
| Solubility | DMSO: soluble20mg/mL, clear |
| Appearance | powder |
| Color | white to beige |
| Storage Condition | 2-8°C |
| In vitro study | L002 also has weak inhibitory effects against PCAF and GCN5 (IC 50 s =35 and 34 µM, respectively) and is specific for p300 over a panel of additional acetyltransferases, deacetylases, and methyltransferases. |
NSC764414 - Risk and Safety
| WGK Germany | 3 |
NSC764414 - Reference Information
| biological activity | L002 is a potent, cell-permeable, A reversible and specific acetyltransferase p300(KAT3B) inhibitor with an IC50 of 1.98 μm. L002 binds to the acetyl-CoA pocket and competitively inhibits the FATp300 catalytic domain, blocks histone acetylation and p53 acetylation, and inhibits STAT3 activation. L002 has the potential to be used in the study of cardiac hypertrophy and fibrosis caused by hypertension. |
| Target | IC50: 1.98 uM (KAT3B); 35 µm (PCAF); 34 µm (GCN5) ;STAT3; p53 |
| Animal Model: | Wild‐type C57BL/6 male mice planted with osmotic minipumps ( Angiotensin II 1500ng/kg/min) for 4 weeks |
| Dosage: | 20μg/gm body weight; every 3rd day; 2 weeks |
| Administration: | Intraperitoneal injection |
| Result: | Reversed hypertension-induced cardiac fibrosis in mice. |
Last Update：2024-04-09 21:11:58
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Product Name: L002 Visit Supplier Webpage Request for quotationCAS: 321695-57-2
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: L002 Visit Supplier Webpage Request for quotationCAS: 321695-57-2
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: L002(NSC764414) Visit Supplier Webpage Request for quotationCAS: 321695-57-2
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
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