Name | NITD-916 |
Synonyms | NITD-916 2(1H)-Pyridinone, 6-[(4,4-dimethylcyclohexyl)methyl]-4-hydroxy-3-phenyl- |
CAS | 1614262-83-7 |
Molecular Formula | C20H25NO2 |
Molar Mass | 311.42 |
Density | 1.115±0.06 g/cm3(Predicted) |
Boling Point | 488.7±45.0 °C(Predicted) |
pKa | 4.50±1.00(Predicted) |
Storage Condition | 2-8°C,密封,干燥 |
biological activity | NITD-916 is a 4-hydroxy-2-pyridone derivative, it is an orally active and highly lipophilic inhibitor of mycobacterial enoyl reductase InhA with an IC50 of 570 nM. NITD-916 forms a ternary complex with InhA and NADH to prevent entry into the fatty acyl substrate binding pocket. NITD-916 has effective anti tuberculosis effect. |
Target | IC50: 570 nM (InhA) |