N1-Methylpseudouridine
1-methylpseudouridine
CAS: 13860-38-3
Molecular Formula: C10H14N2O6
N1-Methylpseudouridine - Names and Identifiers
N1-Methylpseudouridine - Physico-chemical Properties
| Molecular Formula | C10H14N2O6 |
| Molar Mass | 258.23 |
| Storage Condition | -20℃ |
| Physical and Chemical Properties | Bioactive N1-methyl-pseudouridine (1-Methylpseudouridine) is a methylpseudouridine with better translation performance than 5 mC and 5 mC/N1-methyl-pseudouridine. By increasing ribosome density, N1-methyl-pseudouridine in mRNA enhances translation with eIF2α-dependent and independent mechanisms. |
N1-Methylpseudouridine - Uses and synthesis methods
in vitro studies
Incorporation of N1-methyl-pseudouridine into mRNA modifies mRNAs produced higher amounts of luc than the standard Luc mRNA in HEK293T cells. Incorporation of N1-methyl-pseudouridine nucleoside modification in both Luc and GFP mRNA enhances the initiation step of translation, in part by suppressing eIF2α phosphorylation. In addition, polysome formation and growth on the NN1-methyl-pseudouridine-containing Luc mRNA is enhanced due to the reduction of elongation rate. In all the in vitro translation systems, incorporation of N1-methyl-pseudouridine in Luc and GFP mRNAs dramatically enhanced translation. The N1-methyl-pseudouridine-Luc mRNA is associated with heavier polysomes than Luc mRNA.
In vivo studies
N1-methylpseudouridine-incorporated mRNA outperforms pseudouridine-incorporated mRNA by providing enhanced protein expression and reduced immunogenicity in mammalian cell lines and mice.
N1-methyl-pseudouridine (1-Methylpseudouridine) (20 μg; I .m. or I .d. routes for 21 days) and m5C/ N1-methyl-pseudouridine-modified mRNA respectively have a higher translational capacity than Ψ and m5C/Ψ-modified mRNA in vivo.
Animal Model: 7-week-old Balb/c mice
Dosage: 20 μg
Administration: I .m. or I .d. routes for 21 days
Result: had a higher translational capacity.
Last Update：2024-04-10 22:42:23
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View History
N1-Methylpseudouridine
1H-Pyrazolo[3,4-b]pyridine-1-acetic acid, 3,6-dicyclopropyl-4-(trifluoromethyl)-
Prosta-8(12),13-dien-1-oic acid, 9-(ethoxyimino)-15-[(trimethylsilyl)oxy]-, trimethylsilyl ester, (13E,15S)- (9CI)
METHYL 6-[(4-CHLOROPHENYL)SULFANYL]-5-CYANO-2-METHYLNICOTINATE
5-叠氮基戊-1-醇
1-硬脂酰-2油酰基磷脂酰胆碱
1H-Pyrazolo[3,4-b]pyridine-1-acetic acid, 3,6-dicyclopropyl-4-(trifluoromethyl)-
Prosta-8(12),13-dien-1-oic acid, 9-(ethoxyimino)-15-[(trimethylsilyl)oxy]-, trimethylsilyl ester, (13E,15S)- (9CI)
METHYL 6-[(4-CHLOROPHENYL)SULFANYL]-5-CYANO-2-METHYLNICOTINATE
5-叠氮基戊-1-醇
1-硬脂酰-2油酰基磷脂酰胆碱