Name | N,N-bis(1-methylethyl)formamide |
Synonyms | AI3-18809 TIMTEC-BB SBB007703 DIISOPROPYLFORMAMIDE N-Formyldiisopropylamine N-FORMYLDIISOPROPYLAMINE N,N-DIISOPROPYLFORMAMIDE N,N-dipropan-2-ylformamide Formamide, N,N-diisopropyl- N,N-Bis(1-methylethyl)formamide N,N-bis(1-methylethyl)formamide N,N-Nis(1-methylethyl)formamide. Formamide, N,N-bis(1-methylethyl)- |
CAS | 2700-30-3 |
EINECS | 220-284-1 |
InChI | InChI=1/C7H15NO/c1-6(2)8(5-9)7(3)4/h5-7H,1-4H3 |
InChIKey | UNBDDZDKBWPHAX-UHFFFAOYSA-N |
Molecular Formula | C7H15NO |
Molar Mass | 129.2 |
Density | 0.89 g/mL at 25 °C (lit.) |
Melting Point | 10-11 °C (lit.) |
Boling Point | 196 °C (lit.) |
Flash Point | 167°F |
Water Solubility | Slightly soluble in water. |
Solubility | Chloroform, Methanol (Slightly) |
Vapor Presure | 58.5hPa at 37.8℃ |
Appearance | Oil |
Color | Colourless |
BRN | 1745406 |
pKa | -0.56±0.70(Predicted) |
Storage Condition | Sealed in dry,Room Temperature |
Refractive Index | n20/D 1.437(lit.) |
Safety Description | S23 - Do not breathe vapour. S24/25 - Avoid contact with skin and eyes. |
WGK Germany | 3 |
RTECS | OO3500000 |
HS Code | 29241900 |
LogP | 1.077 at 30℃ |
application | N,N-diisopropylformamide is a formamide compound. Methamide compounds are the products of primary amine compounds or secondary amine compounds synthesized by carbonyl groups, and are formed by introducing carbonyl groups (-CO) between the nitrogen atoms and hydrogen atoms of primary or secondary amine compounds. formamide compounds are a kind of important chemical raw materials, which are generally used as solvents, extractants, and intermediates in organic synthesis such as pharmaceuticals. |
preparation | 255.7g of formic acid with purity of 85% (I .e. 38.3g of water) and 460g of diisopropylamine with purity of 99% are added to a high-pressure reaction kettle with a volume of 1 liter, and a stirrer is started to mix evenly to obtain a homogeneous reaction system. The molar ratio of formic acid to diisopropylamine 1.05:1. While continuing to maintain stirring, the above-mentioned homogeneous reaction system is heated to about 200 ℃, the pressure in the high-pressure reaction kettle rises to about 1.7MPa and does not continue to rise, the reaction is maintained for about 3 hours, the carbon monoxide and water vapor in the high-pressure reaction kettle are emptied and removed, the reaction products are collected, and about 709g of uniform transparent solution is obtained. Chromatographic analysis and comparison of the above reaction products confirmed that N,N-diisopropylformamide was obtained with a concentration of about 72.23%, and the product also contained diisopropylamine with a concentration of about 27.38%. After calculation, the conversion rate of diisopropylamine is above 72% and the selectivity is 99%. The above reaction products were purified and refined by flash dehydration and vacuum distillation, the diisopropylamine was recovered, and the purified product was chromatographed. The purity of the purified product was measured to be about 99.96%, and the refractive index ND(20) was 1.4370, which indicated that N,N-diisopropylformamide with purity higher than 99% was obtained after purification and purification, which reached the reagent standard. |