N-BOC-3-hydroxymethylmorpholine(N-BOC-3-hydroxymethylmorpholine) is an organic compound. The following is a description of its nature, use, preparation and safety information:
Nature:
-Appearance: White solid
-Molecular formula: C12H21NO4
-Molecular weight: 247.3g/mol
-Melting point: 70-72 degrees Celsius
-Boiling point: 338.5 degrees Celsius (expected)
-Solubility: Soluble in some organic solvents such as dichloromethane and ethanol
Use:
- N-BOC-3-hydroxymethylmorpholine-4-carboxylic acid tert-butyl ester is a compound with functional groups, commonly used in organic synthesis as a temporary protective agent for protecting groups (protecting hydroxyl or amine groups).
-It is often used in the synthesis of some biologically active compounds in drug synthesis.
Preparation Method:
N-BOC-3-hydroxymethylmorpholine-4-carboxylic acid tert-butyl ester can be prepared by the following steps:
-Step 1: N-BOC morpholine and formaldehyde are reacted to generate 3-hydroxymethylmorpholine.
-Step 2: The product obtained in step 1 is reacted with tert-butanol and dimethyl sulfoxide, and an excess of triformamidine is added at low temperature to obtain tert-butyl N-BOC-3-hydroxymethylmorpholine-4-carboxylate.
Safety Information:
- N-BOC-3-Hydroxymethylmorpholine-4-carboxylic acid tert-butyl ester should be stored in a dry, cool place.
-During operation, care should be taken to avoid inhaling the dust, vapor or smoke of the compound.
-Wear suitable personal protective equipment such as chemical protective gloves, eye protection and chemical protective face mask when using.
-Follow all relevant safety procedures during storage and handling.